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首页> 外文期刊>Ultrasound in Medicine and Biology >A simulation model for ultrasonic temperature imaging using change in backscattered energy.
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A simulation model for ultrasonic temperature imaging using change in backscattered energy.

机译：利用反向散射能量的变化进行超声温度成像的仿真模型。

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Ultrasound backscattered from tissue has previously been shown theoretically and experimentally to change predictably with temperature in the hyperthermia range, i.e., 37 degrees C to 45 degrees C, motivating use of the change in backscattered ultrasonic energy (CBE) for ultrasonic thermometry. Our earlier theoretical model predicts that CBE from an individual scatterer will be monotonic with temperature, with, e.g., positive change for lipid-based scatterers and negative for aqueous-based scatterers. Experimental results have previously confirmed the presence of these positive and negative changes in one-dimensional ultrasonic signals and in two-dimensional images acquired from in vitro bovine, porcine and turkey tissues. In order to investigate CBE for populations of scatterers, we have developed an ultrasonic image simulation model, including temperature dependence for individual scatterers based on predictions from our theoretical model. CBE computed from images simulated for populations of randomly distributed scatterers behaves similarly to experimental results, with monotonic variation for individual pixel measurements and for image regions. Effects on CBE of scatterer type and distribution, size of the image region and signal-to-noise ratio have been examined. This model also provides the basis for future work regarding significant issues relevant to temperature imaging based on ultrasonic CBE such as effects of motion on CBE, limitations of motion-compensation techniques and accuracy of temperature estimation, including tradeoffs between temperature accuracy and available spatial resolution.
机译：先前已在理论上和实验上显示了从组织反向散射的超声会随着温度在高温范围（即37摄氏度至45摄氏度）内的变化而发生可预测的变化，从而促使人们将反向散射超声能量（CBE）的变化用于超声测温。我们较早的理论模型预测来自单个散射体的CBE随温度变化是单调的，例如，基于脂质的散射体的正变化，而对于基于水的散射体的负变化。实验结果先前已经证实，在一维超声信号以及从体外牛，猪和火鸡组织获得的二维图像中，存在这些正负变化。为了研究散射体总体的CBE，我们开发了一个超声图像仿真模型，其中包括基于理论模型的预测得出的各个散射体的温度依赖性。从针对随机分布的散射体的模拟图像计算出的CBE与实验结果相似，单个像素测量值和图像区域具有单调变化。研究了散射体类型和分布对CBE的影响，图像区域的大小以及信噪比。该模型还为有关基于超声CBE的温度成像相关重大问题的未来工作提供了基础，例如，运动对CBE的影响，运动补偿技术的局限性以及温度估算的准确性，包括温度精度与可用空间分辨率之间的权衡。

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