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首页> 外文期刊>Ultrasound in Medicine and Biology >Tissue ablation accelerated by peripheral scanning mode with high-intensity focused ultrasound: A study on isolated porcine liver perfusion
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Tissue ablation accelerated by peripheral scanning mode with high-intensity focused ultrasound: A study on isolated porcine liver perfusion

机译：高强度聚焦超声通过外围扫描模式加速组织消融：离体猪肝脏灌注的研究

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摘要

The aims of this study were to investigate the feasibility of accelerated tissue ablation using a peripheral scanning mode with high-intensity focused ultrasound (HIFU) and to explore the effect of flow rate on total energy consumption of the target tissues. Using a model of isolated porcine liver perfusion via the portal vein and hepatic artery, we conducted a scanning protocol along the periphery of the target tissues using linear-scanned HIFU to carefully adjust the varying focal depth, generator power, scanning velocity and line-by-line interval over the entire ablation range. Porcine livers were divided into four ablation groups: group 1, n= 12, with dual-vessel perfusion; group 2, n= 11, with portal vein perfusion alone; group 3, n= 10, with hepatic artery perfusion alone; and group 4, n= 11, control group with no-flow perfusion. The samples were cut open consecutively at a thickness of 3 mm, and the actual ablation ranges were calculated along the periphery of the target tissues after triphenyl tetrazolium chloride staining. Total energy consumption was calculated as the sum of the energy requirements at various focal depths in each group. On the basis of the pre-supposed scanning protocol, the peripheral region of the target tissue formed a complete coagulation necrosis barrier in each group with varying dose combinations, and the volume of the peripheral necrotic area did not differ significantly among the four groups (p > 0.05). Furthermore, total energy consumption in each group significantly decreased with the corresponding decrease in flow rate (p < 0.01). This study revealed that the complete peripheral necrosis barrier within the target tissues can defined using linear-scanned HIFU in an isolated porcine liver perfusion model. Additionally, the flow rate in the major hepatic vessels may play an important role in the use of the peripheral ablation mode, and this novel mode of ablation may enhance the therapeutic efficacy and tolerability of the treatment of large tumors using HIFU ablation.
机译：这项研究的目的是研究使用外围扫描模式和高强度聚焦超声（HIFU）进行加速组织消融的可行性，并探讨流速对目标组织总能量消耗的影响。使用通过门静脉和肝动脉的分离猪肝灌注模型，我们使用线性扫描HIFU沿着靶组织的外围进行了扫描方案，以仔细调节变化的焦深，发生器功率，扫描速度和逐行扫描整个消融范围内的间隔时间。猪肝分为四个消融组：第1组，n = 12，双血管灌注;第2组，第2组。第2组，n = 11，仅门静脉灌注;第3组，n = 10，仅肝动脉灌注;组4，n = 11，无血流灌注的对照组。依次切开厚度为3mm的样品，并在三苯基四唑氯化物染色后沿靶组织的外围计算实际消融范围。总能耗计算为每组不同焦深下的能量需求总和。根据预设的扫描方案，目标组的周围区域在每组中以不同的剂量组合形成了一个完整的凝血坏死屏障，并且四组之间的周围坏死面积没有显着差异（p > 0.05）。此外，每组的总能量消耗显着降低，相应地流量也降低（p <0.01）。这项研究表明，在分离的猪肝灌注模型中，可以使用线性扫描的HIFU定义靶组织内的完整外周坏死屏障。另外，主要肝血管中的流速在外周消融模式的使用中可能起重要作用，并且这种新的消融模式可以增强使用HIFU消融治疗大肿瘤的疗效和耐受性。

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