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首页> 外文期刊>Ultrasound in Medicine and Biology >The axial distribution of lesion-site atherosclerotic plaque components: an in vivo volumetric intravascular ultrasound radio-frequency analysis of lumen stenosis, necrotic core and vessel remodeling.
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The axial distribution of lesion-site atherosclerotic plaque components: an in vivo volumetric intravascular ultrasound radio-frequency analysis of lumen stenosis, necrotic core and vessel remodeling.

机译：病变部位动脉粥样硬化斑块成分的轴向分布：管腔狭窄，坏死核心和血管重塑的体内容积血管内超声射频分析。

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摘要

Radio-frequency intravascular ultrasound (IVUS) analysis characterizes atherosclerotic plaques into necrotic core (NC), dense calcium (DC), fibrofatty (FF) and fibrotic (FI) tissue. We studied axial plaque component distribution with respect to stenosis and remodeling. Preintervention virtual histology (VH) IVUS was performed in 81 pts (90 de novo lesions: 43 left anterior descending artery [LAD] and 47 right coronary artery [RCA]). VH-IVUS at the reference, minimum lumen area (MLA) and maximum NC (MaxNC) sites were analyzed. Pullback length of 31.1 +/- 12.0 mm spanned a lesion length of 13.8 +/- 9.5 mm. The MaxNC site was located at the MLA in 3.3% of lesions, proximal to the MLA in 61% of lesions (by 4.11 mm) and distal to the MLA in 35.6% of lesions (by 3.56 mm). The %DC was greater at the MaxNC and %FI and %FF plaque were less than at the MLA site. Lesion fiberoatheromas (FAs) were more often detected at the MaxNC than the MLA (96% versus 51%) and were more often classified as thin-caped or multilayered than the MLA sites. The remodeling index was larger at the MaxNC than MLA sites and correlated with the NC area both at the MLA (r(2) 0.068, p = 0.013) and at the MaxNC (r(2) 0.074, p = 0.009). In conclusion, grey-scale and VH-IVUS analysis showed that the MLA is rarely at the site of greatest instability (largest NC and remodeling) and necrotic core on VH is correlated with remodeling index. These in vivo findings are consistent with previously reported histopathologic data and have important implications for the detection and treatment of coronary artery disease.
机译：射频血管内超声（IVUS）分析将动脉粥样硬化斑块表征为坏死核心（NC），致密钙（DC），纤维脂肪（FF）和纤维化（FI）组织。我们研究了有关狭窄和重塑的轴向斑块成分分布。干预前虚拟组织学（VH）IVUS进行了81分（90个新生病变：43个左前降支[LAD]和47个右冠状动脉[RCA]）。对参考的VH-IVUS，最小管腔面积（MLA）和最大NC（MaxNC）部位进行了分析。 31.1 +/- 12.0 mm的回拉长度跨越13.8 +/- 9.5 mm的病变长度。 MaxNC位点位于3.3％病变处的MLA处，靠近MLA占61％病变处（4.11 mm），而远离MLA占35.6％病变处（3.56 mm）。在MaxNC处，％DC较大，而在MLA部位，％FI和％FF斑块较小。在MaxNC上，病变纤维化动脉瘤（FAs）比MLA更为常见（96％比51％），并且比MLA部位更常被分类为薄帽或多层。 MaxNC处的重塑指数大于MLA部位，并且与MLA（r（2）0.068，p = 0.013）和MaxNC（r（2）0.074，p = 0.009）的NC面积相关。总之，灰度和VH-IVUS分析表明，MLA很少出现在最大不稳定部位（最大NC和重塑），而VH上的坏死核心与重塑指数相关。这些体内发现与先前报道的组织病理学数据一致，并且对冠状动脉疾病的检测和治疗具有重要意义。

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