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首页> 外文期刊>Ultrasound in obstetrics & gynecology: the official journal of the International Society of Ultrasound in Obstetrics and Gynecology >Prenatal detection of trisomy 21 by second-trimester ultrasound examination and maternal age in a non-selected population of 49 314 births in Norway.
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Prenatal detection of trisomy 21 by second-trimester ultrasound examination and maternal age in a non-selected population of 49 314 births in Norway.

机译：在挪威非选择人群中，通过孕中期超声检查和产妇年龄对21三体性进行了产前检测。

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OBJECTIVES: To assess the contribution of the second-trimester routine ultrasound examination and maternal age (>or= 38 years) to the prenatal detection of trisomy 21 in a large non-selected population in which no other screening methods were carried out. METHODS: A prospective follow-up study was carried out in a non-selected Norwegian population from 1987 to 2004, including a total of 49 314 births. Data from all cases of trisomy 21, detected prenatally by karyotyping following amniocentesis performed for abnormal ultrasound findings or because of maternal age >or= 38 years, or postnatally after delivery, were registered. The study period was divided into three 6-year periods. RESULTS: Eighty-eight cases of trisomy 21 were registered. The prenatal detection rate was 43% (38/88). No significant change in the detection rate was observed over the 18 years. Fourteen percent (12/88) of cases were detected as a result of advanced maternal age and 30% (26/88) by prenatal ultrasound examination. Of all womenwith a trisomy 21 fetus, 72% (63/88) were under 38 years of age. The percentage of women >or= 38 years opting for karyotyping during the three time periods decreased significantly from 51% to 50% and 36%, respectively. The termination rate of trisomy 21 fetuses was 84%, with no significant change over time. CONCLUSIONS: Our data can be considered as a reference standard for population screening for trisomy 21 based solely on maternal age and second-trimester ultrasound imaging. The prenatal detection rate of trisomy 21 cases was poor and remained unchanged throughout the 18-year study period. If improvement in detection rates is desired, additional programs are necessary.
机译：目的：评估未选择其他大筛查人群的孕中期常规超声检查和产妇年龄（> = 38岁）对21号三体症产前检测的贡献。方法：从1987年至2004年，在非选择的挪威人群中进行了一项前瞻性随访研究，包括49 314例婴儿。记录了所有21三体性病例的数据，这些数据是在进行羊膜穿刺术后通过核型分型在产前检查的，以发现异常的超声发现或由于产妇年龄大于或等于38岁，或在分娩后进行。研究期分为三个6年期。结果：登记了88例三体性21例。产前检出率为43％（38/88）。在过去的18年中，发现率没有明显变化。孕产妇年龄增加的结果中发现了百分之十四（12/88），产前超声检查发现了百分之三十（26/88）。在21三体胎儿的所有女性中，有72％（63/88）在38岁以下。在这三个时间段内选择核型分析的38岁或以上的女性百分比分别从51％显着降低到50％和36％。 21三体胎儿的终止率是84％，随时间变化无明显变化。结论：我们的数据可被视为仅基于产妇年龄和孕中期超声影像学筛查21三体的人群的参考标准。在18年的研究期内，三体性21例的产前检测率很低，并且保持不变。如果需要提高检测率，则需要其他程序。

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