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首页> 外文期刊>Ultrasound in obstetrics & gynecology: the official journal of the International Society of Ultrasound in Obstetrics and Gynecology >Middle cerebral artery blood flow velocities and pulsatility index and the cerebroplacental pulsatility ratio: longitudinal reference ranges and terms for serial measurements.
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Middle cerebral artery blood flow velocities and pulsatility index and the cerebroplacental pulsatility ratio: longitudinal reference ranges and terms for serial measurements.

机译：脑中动脉血流速度和搏动指数以及脑胎盘搏动比：纵向参考范围和连续测量项。

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OBJECTIVES: To establish reference ranges suitable for serial assessments of the fetal middle cerebral (MCA) and umbilical (UA) artery blood flow velocities, pulsatility index (PI) and cerebroplacental pulsatility ratio and to provide terms for calculating conditional reference intervals suitable for individual serial measurements. METHODS: This was a longitudinal study of 161 singleton pregnancies. Using Doppler ultrasound, MCA and UA blood velocities and PI were determined three to five times at 3-5-week intervals over a gestational age range of 19-41 weeks. Polynomial regression lines for the 95th, 50th and 5th percentiles were calculated for the peak systolic velocity (PSV), time-averaged maximum velocity (TAMXV), PI and cerebroplacental ratio. Terms for calculating conditional reference intervals were established. RESULTS: Based on 566 observations our new longitudinal reference ranges for fetal middle cerebral PSV, TAMXV and PI provided terms for calculating conditional reference intervals (i.e. predicting expected 95% confidence limits based on a previous measurement), and correspondingly for the cerebroplacental ratio (n = 550). The reference ranges were at some variance with those of previous cross-sectional studies. The narrow 95% confidence limits for the 5(th) and 95(th) percentiles ensured reliable ranges. CONCLUSIONS: We have established longitudinal reference ranges appropriate for the serial assessment of MCA blood velocities and PI and cerebroplacental ratio. Particularly the terms for calculating conditional ranges based on a previous observation make this system more appropriate for longitudinal monitoring than are cross-sectional data.
机译：目的：建立适合连续评估胎儿中脑（MCA）和脐带（UA）血流速度，搏动指数（PI）和脑胎盘搏动比率的参考范围，并提供条件来计算适用于个别序列的条件参考区间测量。方法：这是对161例单胎妊娠的纵向研究。使用多普勒超声，在19-41周的胎龄范围内，每3-5周间隔三到五次测定MCA和UA的血流速度和PI。计算了95、50和5个百分位数的多项式回归线，以计算收缩期峰值速度（PSV），时平均最大速度（TAMXV），PI和脑胎盘比率。建立了用于计算条件参考间隔的术语。结果：基于566项观察，我们针对胎儿中脑PSV，TAMXV和PI的新纵向参考范围为计算条件参考间隔（即根据先前的测量预测预期的95％置信范围）以及相应的脑-胎盘比（n = 550）。参考范围与以前的横断面研究有所不同。第5个和第95个百分点的狭窄95％置信度确保了可靠的范围。结论：我们建立了适合于连续评估MCA血流速度，PI和脑胎盘比例的纵向参考范围。特别是，基于先前的观察结果计算条件范围的术语使该系统比横截面数据更适合于纵向监视。

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