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首页> 外文期刊>Chemistry: A European journal >High-relaxivity magnetic resonance imaging (MRI) contrast agent based on supramolecular assembly between a gadolinium chelate, a modified dextran, and poly-beta-cyclodextrin
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High-relaxivity magnetic resonance imaging (MRI) contrast agent based on supramolecular assembly between a gadolinium chelate, a modified dextran, and poly-beta-cyclodextrin

机译：基于a螯合物，修饰的葡聚糖和聚-β-环糊精之间的超分子组装的高弛豫性磁共振成像（MRI）造影剂

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摘要

Nanosized contrast agents have great potential in magnetic resonance molecular imaging applications for clinical diagnosis. This study proposes new nanoparticles spontaneously formed under mild conditions and composed of a noncovalent adduct between a gadolinium complex, a polymer of P-cyclodextrin (p beta CD: MW 1.5 x 10(6) g mol(-1)) and a dextran grafted with alkyl chains (MD). The formation of this supramolecular nanoassembly is based upon a "lock-and-key" recognition process in which the hydrophobic alkyl chains of MD and the adamantyl moieties of macrocyclic Gd-III chelates are included in the cavities of p beta CD. The large number of beta CDs contained in the p beta CD resulted in the formation of 200 nm diameter nanoparticles, each entrapping 1.8 x 10(5) molecules of a low-molecular-weight Gd complex. This system, which exhibits a great relaxivity enhancement (48.4 mM(-1) s(-1), at 20 MHz and 37 degrees C) compared to the Gd-III chelate itself (5.2 mM(-1) s(-1)), appears to be a promising strategy for the in vivo targeted delivery of Gd-III complexes. The mechanisms of particle formation, conjugation strategies, and relaxometric characterizations in the field of contrast-enhanced magnetic resonance imaging are discussed.
机译：纳米级造影剂在磁共振分子成像应用中具有巨大的临床诊断潜力。这项研究提出了在温和条件下自发形成的新型纳米颗粒，该纳米颗粒由a配合物，P-环糊精聚合物（p beta CD：MW 1.5 x 10（6）g mol（-1））和接枝的葡聚糖之间的非共价加合物组成。烷基链（MD）。该超分子纳米组装体的形成基于“锁钥”识别过程，其中MD的疏水烷基链和大环Gd-III螯合物的金刚烷基部分包括在ββCD的空腔中。 p beta CD中包含的大量beta CD导致形成直径为200 nm的纳米颗粒，每个纳米颗粒都捕获了1.8 x 10（5）分子的低分子量Gd复合物。与Gd-III螯合物本身（5.2 mM（-1）s（-1）相比，该系统显示出极大的弛豫度增强（在20 MHz和37摄氏度下为48.4 mM（-1）s（-1）。 ），对于体内靶向递送Gd-III复合物似乎是一种有前途的策略。讨论了造影剂增强磁共振成像领域中的颗粒形成机理，共轭策略和弛豫特征。

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