A Multicomponent Reaction Towards N-(Cyanomethyl)amides

Niels Elders; Eelco Ruijter; Frans J. J. de Kanter; Elwin Janssen; Martin Lutz; Anthony L. Spek; Romano V. A. Orru

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A Multicomponent Reaction Towards N-(Cyanomethyl)amides

机译：N-（氰基甲基）酰胺的多组分反应

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Multicomponent reactions (MCRs)[1] have emerged as useful tools in diversity-oriented synthesis (DOS).[2] Although a number of substituents can be varied over a broad range, MCRs often access products of one specific scaffold, limiting the overall chemical diversity. To overcome this, MCRs have been combined with other types of reactions such as Diels–Alder reactions,[3] click chemistry,[4] and cyclization strategies[5] to generate structural diversity and a high degree of complexity in a minimal number of reaction steps. Our group contributed in this field by trapping 1-azadienes,[ 6] generated by the three-component reaction (3-CR) between phosphonates, nitriles and aldehydes,[7] with various reactants resulting in novel 4-CRs for a variety of heterocyclic scaffolds.[8]

机译：多组分反应[MCR] [1]已经成为面向多样性的综合（DOS）[2]中的有用工具。尽管许多取代基可以在很宽的范围内变化，但MCR通常会接触一种特定支架的产物，从而限制了整体化学多样性。为了克服这个问题，MCR已与其他类型的反应（例如Diels–Alder反应，[3]点击化学反应[4]和环化策略[5]）结合使用，以最小的数量产生结构多样性和高度复杂性反应步骤。我们小组在该领域中做出了贡献，将1-氮杂二烯[6]与膦酸酯，腈和醛之间的三组分反应（3-CR）[7]与各种反应物结合，产生了适用于各种杂环支架。[8]

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《Chemistry: A European journal》 |2009年第25期|共4页
作者
Niels Elders; Eelco Ruijter; Frans J. J. de Kanter; Elwin Janssen; Martin Lutz; Anthony L. Spek; Romano V. A. Orru;
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正文语种 eng
中图分类应用化学;
关键词
generate structural; access products; three-component;

机译：产生结构;获取产品;三要素;

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1. A Multicomponent Reaction Towards N-(Cyanomethyl)amides [J] . Niels Elders, Eelco Ruijter, Frans J. J. de Kanter, Chemistry: A European journal . 2009,第25期

机译：N-（氰基甲基）酰胺的多组分反应
2. Comparative studies on the amidoalkylating properties of N-(1-methoxyalkyl)amides and 1-(N-acylamino)alkyltriphenylphosphonium salts in the michaelis-arbuzov-like reaction: A new one-pot transformation of N-(1-methoxyalkyl)amides into phosphonic or phosphinic analogs of N-Acyl-α-amino acids [J] . Adamek J., Pa?dzierniok-Holewa A., Zielińska K., Phosphorus, Sulfur, and Silicon and the Related Elements . 2013,第7a9期

机译：N-（1-甲氧基烷基）酰胺和1-（N-酰基氨基）烷基三苯基phosph盐在迈克尔斯-阿布佐夫样反应中的酰胺基烷基化性质的比较研究：N-（1-甲氧基烷基）酰胺向一锅法的新转化N-酰基-α-氨基酸的膦酸或次膦酸类似物
3. Elimination of benzotriazolyl group in N-(alpha-benzotriazol-1-ylalkyl)amides and N-(alpha-benzotriazol-1-ylalkyl)sulfonamides: their self-coupling and cross-coupling reactions with carbonyl compounds [J] . Wang XX., Liu YJ., Zhang YM. Tetrahedron . 2003,第41期

机译：消除N-（α-苯并三唑-1-基烷基）磺酰胺和N-（α-苯并三唑-1-基烷基）磺酰胺中的苯并三唑基：它们与羰基化合物的自偶联和交叉偶联反应
4. MESOPOROUS IRON ALUMINOPHOSPHATE: AN EFFICIENT CATALYST FOR ONE POT SYNTHESIS OF AMIDES BY ESTER-AMIDE EXCHANGE REACTION [C] . A.V. Vijayasankar, H. Kathyayini, Harikrishna Tumma, International Symposium on Inorganic Phosphate Materials : Phosphate Materials for Energy Storage . 2012

机译：中孔铁铝磷酸酯：通过酯 - 酰胺交换反应的一种罐合成酰胺的有效催化剂
5. Multicomponent Reaction to Synthesize 3,5-Dicyano-6-Sulfanylpyridine and its Derivatieves =MULTICOMPONENT REACTION TO SYNTHESIZE 3,5-DICYANO-6-SULFANYLPYRIDINE AND ITS DERIVATIEVES [D] . Almotairi, Mayasim. 2018

机译：合成3,5-二氰-6-磺酰吡啶及其衍生物的多组分反应=多组分反应合成3,5-二氰-6-磺酰吡啶及其衍生物
6. Copper-Catalyzed Three- Five- or Seven-Component Coupling Reactions: The Selective Synthesis of Cyanomethylamines NN-Bis(Cyanomethyl)Amines and NN-Bis(Cyanomethyl)Methylenediamines Based on a Strecker-Type Synthesis [O] . Norio Sakai, Nobuaki Takahashi, Daiki Inoda, 2013

机译：铜催化的三元或五元或七元偶联反应：基于Strecker型合成的氰基甲胺NN-双（氰基甲基）胺和NN-双（氰基甲基）亚甲基二胺的选择性合成
7. Reaction of N-(Dialkylaminomethyl) amides and N-(α-Dialkylaminobenzyl) amides with Sulfides and Cyanide [O] . HIDEO SAKAI, KEIICHI ITO, MINORU SEKIYA 1973

机译：N-（二烷基氨基甲基）酰胺和N-（α-二烷基氨基苄基）酰胺与硫化物和氰化物的反应
8. EPA Pesticide Fact Sheet: (CAS) N-(cyanomethyl) -4-(trifluoromethyl) -3-(pyridinecarboximide) or (UPAC) N-cyanomethyl-4-trifluoromethyl nicotinamide (Flonicamid) [R] . 2004

机译：Epa农药事实表：（Cas）N-（氰基甲基）-4-（三氟甲基）-3-（吡啶羧酰亚胺）或（UpaC）N-氰基甲基-4-三氟甲基烟酰胺（Flonicamid）

A Multicomponent Reaction Towards N-(Cyanomethyl)amides

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