Organocatalytic Tandem Reaction to Construct Six-Membered Spirocyclic Oxindoles with Multiple Chiral Centres through a Formal [2+2+2] Annulation

Jiang K; Jia ZJ; Chen S; Wu L; Chen YC

首页> 外文期刊>Chemistry: A European journal >Organocatalytic Tandem Reaction to Construct Six-Membered Spirocyclic Oxindoles with Multiple Chiral Centres through a Formal [2+2+2] Annulation

【24h】

Organocatalytic Tandem Reaction to Construct Six-Membered Spirocyclic Oxindoles with Multiple Chiral Centres through a Formal [2+2+2] Annulation

机译：通过形式的[2 + 2 + 2]环状结构构筑具有多个手性中心的六元螺环氧化吲哚的有机催化串联反应

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

An efficient tandem reaction for the asymmetric synthesis of six-membered spirocyclic oxindoles has been successfully developed through a formal [2+ 2+2] annulation strategy. The amine-catalysed stereoselective Michael addition of aliphatic aldehydes to electron-deficient olefinic oxindole motifs gave chiral C3 components, which were further combined with diverse electrophiles (activated olefins or imines) to afford spirocyclic oxindoles with versatile molecular complexity (up to six contiguous stereogenic centres, high diastereo- and enantioselectivities).

机译：通过正式的[2+ 2 + 2]环空策略已成功开发了一种有效的串联反应，用于六元螺环氧吲哚的不对称合成。胺催化的脂肪族醛的胺催化立体选择性迈克尔加成至缺电子的烯属羟吲哚基序，得到手性C3组分，将其进一步与各种亲电试剂（活化的烯烃或亚胺）结合，可得到具有多种分子复杂性的螺环羟吲哚（最多六个连续的立体异构中心），高非对映选择性和对映选择性）。

著录项

来源
《Chemistry: A European journal》 |2010年第9期|共5页
作者
Jiang K; Jia ZJ; Chen S; Wu L; Chen YC;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类应用化学;
关键词
synthesis; addition; centres;

机译：综合;加法;中心;

相似文献

外文文献
中文文献
专利

1. Organocatalytic Tandem Reaction to Construct Six-Membered Spirocyclic Oxindoles with Multiple Chiral Centres through a Formal [2+2+2] Annulation [J] . Jiang K, Jia ZJ, Chen S, Chemistry: A European journal . 2010,第9期

机译：通过形式的[2 + 2 + 2]环状结构构筑具有多个手性中心的六元螺环氧化吲哚的有机催化串联反应
2. Organocatalytic, Asymmetric [2+2+2] Annulation to Construct Six-Membered Spirocyclic Oxindoles with Six Continuous Stereogenic Centers [J] . Zhi-Long Li, Chao Liu, Rui Tan, Catalysts . 2016,第5期

机译：有机催化，不对称[2 + 2 + 2]环构造具有六个连续立体中心的六元螺环氧化吲哚。
3. Organocatalytic formal [5+1] annulation: Diastereoselective cascade synthesis of functionalized six-membered spirocyclic indane-1,3-diones/oxindoles via Michael-aldol reaction [J] . Roy S., Amireddy M., Chen K. Tetrahedron . 2013,第41期

机译：有机催化正式[5 + 1]环空：通过Michael-aldol反应的功能化六元螺环茚满-1,3-二酮/羟吲哚的非对映选择性级联合成
4. Organocatalytic Reactions with Novel Chiral Hypervalent Iodine Compounds(Abstracts) [C] . Robert D. Richardson, Sabine Altermann, Thomas Wirth European Symposium on Organic Chemistry . 2007

机译：与新型手性高效碘化物（摘要）有机催化反应
5. Development of palladium-catalyzed and iodine-mediated formal [4+1] annulation protocols. Progress toward a new fulvene-based organocatalytic platform for carbonyl α-functionalization. [D] . Coscia, Rockford Winthrop 2011

机译：钯催化和碘介导的正式[4 + 1]环空方案的开发。向羰基α-官能化的新的基于富烯的有机催化平台的进展。
6. Diastereoselection in the Formation of Spirocyclic Oxindoles by the Intramolecular Heck Reaction [O] . Larry E. Overman, Donald A. Watson -1

机译：通过分子内Heck反应形成螺旋环吲哚的非对映选择性
7. Organocatalytic, Asymmetric [2+2+2] Annulation to Construct Six-Membered Spirocyclic Oxindoles with Six Continuous Stereogenic Centers [O] . Zhi-Long Li, Chao Liu, Rui Tan, 2016

机译：有机催化，不对称[2 + 2 + 2]环化构建6个连续立体中心的六元螺环氧吲哚

Organocatalytic Tandem Reaction to Construct Six-Membered Spirocyclic Oxindoles with Multiple Chiral Centres through a Formal [2+2+2] Annulation

摘要

著录项

相似文献

相关主题

期刊订阅