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Simulations of adaptive temperature control with self-focused hyperthermia system for tumor treatment

机译：自聚焦热疗系统自适应温度控制在肿瘤治疗中的模拟

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The control problem in ultrasound therapy is to destroy the tumor tissue while not harming the intervening healthy tissue with a desired temperature elevation. The objective of this research is to present a robust and feasible method to control the temperature distribution and the temperature elevation in treatment region within the prescribed time, which can improve the curative effect and decrease the treatment time for heating large tumor (≥2.0 cm in diameter). An adaptive self-tuning-regulator (STR) controller has been introduced into this control method by adding a time factor with a recursive algorithm, and the speed of sound and absorption coefficient of the medium is considered as a function of temperature during heating. The presented control method is tested for a self-focused concave spherical transducer (0.5 MHz, 9 cm aperture, 8.0 cm focal length) through numerical simulations with three control temperatures of 43 °C, 50 °C and 55 °C. The results suggest that this control system has adaptive ability for variable parameters and has a rapid response to the temperature and acoustic power output in the prescribed time for the hyperthermia interest. There is no overshoot during temperature elevation and no oscillation after reaching the desired temperatures. It is found that the same results can be obtained for different frequencies and temperature elevations. This method can obtain an ellipsoid-shaped ablation region, which is meaningful for the treatment of large tumor.
机译：超声治疗中的控制问题是破坏肿瘤组织，同时不以期望的温度升高伤害介入的健康组织。本研究的目的是提出一种鲁棒而可行的方法，以在规定的时间内控制治疗区域内的温度分布和温度升高，以提高疗效并减少加热大肿瘤（≥2.0cm）的治疗时间直径）。通过将时间因子与递归算法相加，已将自适应自调谐调节器（STR）控制器引入此控制方法，并且将声速和介质的吸收系数视为加热过程中温度的函数。通过在43°C，50°C和55°C的三个控制温度下进行数值模拟，对所提出的控制方法进行了测试，以针对自聚焦凹面球形换能器（0.5 MHz，9 cm孔径，8.0 cm焦距）进行了测试。结果表明，该控制系统具有针对可变参数的自适应能力，并在规定的时间内对感兴趣的高温疗法具有对温度和声功率输出的快速响应。在温度升高期间不会出现过冲，在达到所需温度后也不会发生振荡。发现对于不同的频率和温度升高可以获得相同的结果。这种方法可以获得椭圆形的消融区域，这对于治疗大肿瘤是有意义的。

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