One-Step Synthesis of Folic Acid Protected Gold Nanoparticles and TheirReceptor-Mediated Intracellular Uptake

Gaiping Li; Dan Li; Lixue Zhang; Junfeng Zhai; Erkang Wang

首页> 外文期刊>Chemistry: A European journal >One-Step Synthesis of Folic Acid Protected Gold Nanoparticles and TheirReceptor-Mediated Intracellular Uptake

【24h】

One-Step Synthesis of Folic Acid Protected Gold Nanoparticles and TheirReceptor-Mediated Intracellular Uptake

机译：叶酸保护的金纳米粒子的一步合成及其受体介导的细胞内摄取

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

We report here a facilemethod to obtain folic acid (FA)-pro-tected gold nanoparticles (Au NPs) byheating an aqueous solution ofHAuCl_4/FA in which acts as boththe reducing and stabilizing agent. Thesuccessful formation of FA-protectedAu NPs is demonstrated by UV/Visspectroscopy, transmission electron mi-croscopy (TEM), selected-area electrondiffraction (SAED), X-ray photoelec- tron spectroscopy (XPS), and Fouriertransform infrared spectroscopy(FTIR). The intracellular uptake ofthese nanoparticles is facilitated byHeLa cells overexpressing the folatereporter, which itself is significantly in-hibited by free FA in a competitiveassay as quantified by inductively cou-pled plasma mass spectroscopy (ICP-MS). This simple one-step approach af-fords a new perspective for creatingfunctional nanomaterials, and the re-sulting biocompatible, functional AuNPs may find some prospective appli-cations in various biomedical fields.

机译：我们在这里报告了一种简便的方法，通过加热用作还原剂和稳定剂的HAuCl_4 / FA的水溶液来获得受叶酸（FA）保护的金纳米颗粒（Au NPs）。通过紫外/可见光谱，透射电子显微镜（TEM），选择区域电子衍射（SAED），X射线电子光谱（XPS）和傅里叶变换红外光谱（FTIR）证明了FA保护的Au NP的成功形成。这些纳米粒子的细胞内摄取是由过表达叶酸报告的HeLa细胞促进的，叶酸报告物本身在竞争性测定中被游离FA显着抑制，如电感耦合等离子体质谱（ICP-MS）所定量。这种简单的一步方法为创建功能性纳米材料提供了新的视角，而最终得出的生物相容性，功能性AuNPs可能会在各种生物医学领域中找到一些潜在的应用。

著录项

来源
《Chemistry: A European journal》 |2009年第38期|共6页
作者
Gaiping Li; Dan Li; Lixue Zhang; Junfeng Zhai; Erkang Wang;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类应用化学;
关键词
competitive inhibition; folic acid; gold; nanoparticles; reporter-mediated uptake;

机译：竞争抑制;叶酸;金;纳米颗粒;报告介导的摄取;

相似文献

外文文献
中文文献
专利

1. One-Step Synthesis of Folic Acid Protected Gold Nanoparticles and TheirReceptor-Mediated Intracellular Uptake [J] . Gaiping Li, Dan Li, Lixue Zhang, Chemistry: A European journal . 2009,第38期

机译：叶酸保护的金纳米粒子的一步合成及其受体介导的细胞内摄取
2. Shaping and Cellular Uptake of Folic Acid Coated Gold and Magnetite Nanoparticles [J] . Ahmed A.G. El-Shahawy, Gamal Elghnam, Alsayed A.M. Alsherbini Current nanomedicine . 2019,第2期

机译：叶酸涂层金和磁铁矿纳米粒子的成型和细胞吸收
3. Synthesis of gold nanoparticles using pH-sensitive hydrogel and its application for colorimetric determination of acetaminophen, ascorbic acid and folic acid [J] . Morteza Bahram, Fariba Hoseinzadeh, Khalil Farhadi, Colloids and Surfaces, A. Physicochemical and Engineering Aspects . 2014,第Null期

机译：pH敏感水凝胶合成金纳米颗粒及其在对乙酰氨基酚，抗坏血酸和叶酸的比色测定中的应用
4. Intracellular uptake of poly(ethylene glycol) and folic acid modified magnetite nanoparticles [C] . Yong Zhang, Nathan Kohler, Miqin Zhang Symposium on "Synthesis, Functional Properties and Applications of Nanostructures" . 2002

机译：聚（乙二醇）和叶酸改性磁铁矿纳米粒子的细胞内吸收
5. Synthesis and characterization of monolayer protected gold nanoparticles and a gold-titanium dioxide nanocomposite intended for photocatalytic degradation of environmental pollutants. [D] . Amaratunga, Piyadarsha. 2010

机译：单层保护的金纳米颗粒和金-二氧化钛纳米复合材料的合成与表征，旨在光催化降解环境污染物。
6. Synergistically enhanced selective intracellular uptake of anticancer drug carrier comprising folic acid-conjugated hydrogels containing magnetite nanoparticles [O] . Haneul Kim, Ara Jo, Seulgi Baek, -1

机译：协同增强的抗癌药物载体的选择性细胞内摄取该载体包含叶酸结合的含磁铁矿纳米颗粒的水凝胶
7. Microwave-assisted one-step rapid synthesis of folic acid modified gold nanoparticles for cancer cell targeting and detection [O] . Zhang Zhaowu, Jia Jing, Ma Yanyan, 2011

机译：微波辅助一步法快速合成叶酸修饰金纳米粒子用于癌细胞靶向和检测

One-Step Synthesis of Folic Acid Protected Gold Nanoparticles and TheirReceptor-Mediated Intracellular Uptake

摘要

著录项

相似文献

相关主题

期刊订阅