#alpha#-LNA(Locked Nucleic Acid with #alpha#-D-Configuration): Synthesis and Selective Parallel Recognition of RNA

Poul Nielsen; Nanna K.Christensen; Jakob K.Dalskov

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#alpha#-LNA(Locked Nucleic Acid with #alpha#-D-Configuration): Synthesis and Selective Parallel Recognition of RNA

机译：＃alpha＃-LNA（具有＃alpha＃-D-构型的锁定核酸）：RNA的合成和选择性并行识别

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#alpha#-LNA is presented as a stereoisomer of LNA (locked nucleic acid ) with #alpha#-D--configuration. Three different approaches towards the thymine #alpha#-LNA monomer as well as the 5-methulcytosine #alpha#-LNA monomer are presented. Different #alpha#-LNA sequences have been synthesised and their hybridisation with complementary DNA and RNA has been evaluted by means of thermal stability experiments and circular dichroism spectroscopy. In a mixed pyrimidine sequence, -LNA displays unprecedented paralled-starnded and selective RNA binding . Furthermore, a remarkable selectivity for hybridisation with RNA over DNA is indicated

机译：＃alpha＃-LNA是具有＃alpha＃-D--构型的LNA（锁核酸）的立体异构体。提出了针对胸腺嘧啶＃alpha＃-LNA单体以及5-甲硫胞嘧啶＃alpha＃-LNA单体的三种不同方法。已合成了不同的＃alpha＃-LNA序列，并已通过热稳定性实验和圆二色谱法评估了它们与互补DNA和RNA的杂交。在混合的嘧啶序列中，-LNA显示出前所未有的平行星标和选择性RNA结合。此外，显示了与RNA相比在DNA上具有非凡的选择性

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《Chemistry: A European journal》 |2002年第3期|共11页
作者
Poul Nielsen; Nanna K.Christensen; Jakob K.Dalskov;
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正文语种 eng
中图分类化学;应用化学;
关键词
locked nucleic acid; nucleosides; oligonucletotides; RNA recognition;

机译：锁核酸核苷寡核苷酸RNA识别;

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1. #alpha#-LNA(Locked Nucleic Acid with #alpha#-D-Configuration): Synthesis and Selective Parallel Recognition of RNA [J] . Poul Nielsen, Nanna K.Christensen, Jakob K.Dalskov Chemistry: A European journal . 2002,第3期

机译：＃alpha＃-LNA（具有＃alpha＃-D-构型的锁定核酸）：RNA的合成和选择性并行识别
2. A bridged nucleic acid, 2′,4′-BNACOC: synthesis of fully modified oligonucleotides bearing thymine, 5-methylcytosine, adenine and guanine 2′,4′-BNACOC monomers and RNA-selective nucleic-acid recognition [J] . Ryo Ohnishi, Satoshi Obika, Takeshi Imanishi, Nucleic acids research . 2009,第4期

机译：桥接核酸2'，4'-BNACOC：带有胸腺嘧啶，5-甲基胞嘧啶，腺嘌呤和鸟嘌呤2'，4'-BNACOC单体的完全修饰寡核苷酸的合成和RNA选择性核酸识别
3. A bridged nucleic acid, 2′,4′-BNACOC: synthesis of fully modified oligonucleotides bearing thymine, 5-methylcytosine, adenine and guanine 2′,4′-BNACOC monomers and RNA-selective nucleic-acid recognition [J] . Ryo Ohnishi, Satoshi Obika, Takeshi Imanishi, Nucleic acids research . 2009,第4期

机译：桥接核酸2'，4'-BNACOC：带有胸腺嘧啶，5-甲基胞嘧啶，腺嘌呤和鸟嘌呤2'，4'-BNACOC单体的完全修饰寡核苷酸的合成和RNA选择性核酸识别
4. Recognition of Chromosomal DNA in Human Cells by Peptide Nucleic Acids and Small Duplex RNAs [C] . DAVID R. COREY NIH Symposium on Therapeutic Oligonucleotides . 2005

机译：肽核酸和小双相RNA识别人体细胞中的染色体DNA
5. The design and synthesis of coordination compounds for the selective recognition of nucleic acids, and, Studies on the cooperative recognition properties of fluorescent receptors. [D] . Jones, Paul D. 2003

机译：设计和合成用于选择性识别核酸的配位化合物，以及荧光受体协同识别特性的研究。
6. A bridged nucleic acid 2′4′-BNACOC: synthesis of fully modified oligonucleotides bearing thymine 5-methylcytosine adenine and guanine 2′4′-BNACOC monomers and RNA-selective nucleic-acid recognition [O] . Yasunori Mitsuoka, Tetsuya Kodama, Ryo Ohnishi, 2009

机译：桥接核酸24-BNACOC：带有胸腺嘧啶5-甲基胞嘧啶腺嘌呤和鸟嘌呤24-BNACOC单体的完全修饰寡核苷酸的合成和RNA选择性核酸识别
7. A bridged nucleic acid, 2′,4′-BNACOC: synthesis of fully modified oligonucleotides bearing thymine, 5-methylcytosine, adenine and guanine 2′,4′-BNACOC monomers and RNA-selective nucleic-acid recognition [O] . Mitsuoka, Yasunori, Kodama, Tetsuya, Ohnishi, Ryo, 2009

机译：桥接核酸2'，4'-BNACOC：带有胸腺嘧啶，5-甲基胞嘧啶，腺嘌呤和鸟嘌呤2'，4'-BNACOC单体的完全修饰寡核苷酸的合成和RNA选择性核酸识别
8. Locked Nucleic Acid Flow Cytometry-fluorescence in situ Hybridization (LNA flow-FISH): A Method for Bacterial Small RNA Detection [R] . Robertson, K. L., Vora, G. J. 2012

机译：锁核酸流式细胞仪 - 荧光原位杂交（LNa flow-FIsH）：一种细菌小RNa检测方法

#alpha#-LNA(Locked Nucleic Acid with #alpha#-D-Configuration): Synthesis and Selective Parallel Recognition of RNA

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