Hopeahainol A: An acetylcholinesterase inhibitor from Hopea hainanensis

Ge HM; Zhu CH; Shi DH; Zhang LD; Xie DQ; Yang J; Ng SW; Tan RX

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Hopeahainol A: An acetylcholinesterase inhibitor from Hopea hainanensis

机译：Hopeahainol A：海南Hopea的乙酰胆碱酯酶抑制剂

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A phytochemical study of Hopea hainanensis has led to the isolation of three new polyphenols and one known compound. The most important of these compounds are hopeahainols A (2) and B (3), which contain an unprecedented carbon skeleton. The structures were elucidated by analysis of the spectroscopic data including single-crystal X-ray spectroscopy and computational methods. Hopeahainol A was an acetylcholinesterase inhibitor with an IC50 value of 4.33 mu m, which is comparable to that of huperzine A, a presently prescribed drug for the treatment of Alzheimer, while other similar structures were inactive. This observation was complemented by a 3D interaction model of the inhibitor with active sites.

机译：对海南希望树的植物化学研究导致分离出三种新的多酚和一种已知的化合物。这些化合物中最重要的是盼豆酚A（2）和B（3），它们含有前所未有的碳骨架。通过分析光谱数据，包括单晶X射线光谱和计算方法，阐明了结构。 Hopeahainol A是一种乙酰胆碱酯酶抑制剂，IC50值为4.33μm，与目前用于治疗阿尔茨海默氏症的石杉碱A相当，而其他类似结构没有活性。该观察结果得到了具有活性位点的抑制剂的3D相互作用模型的补充。

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《Chemistry: A European journal》 |2008年第1期|共6页
作者
Ge HM; Zhu CH; Shi DH; Zhang LD; Xie DQ; Yang J; Ng SW; Tan RX;
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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
hopeahainol; inhibitor; natural products; polyphenols; structure elucidation; STEM BARK; ALZHEIMERS-DISEASE; COMPLEX; OLIGOSTILBENES; EXALATA; POTENT;

机译：霍普海诺酚;抑制剂;天然产物;多酚;结构解析;茎皮;ALZHEIMERS-疾病;复合物;寡糖;EXALATA;作用力;

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1. Hopeahainol A: An acetylcholinesterase inhibitor from Hopea hainanensis [J] . Ge HM, Zhu CH, Shi DH, Chemistry: A European journal . 2008,第1期

机译：Hopeahainol A：海南Hopea的乙酰胆碱酯酶抑制剂
2. Hopeahainol A binds reversibly at the acetylcholinesterase (AChE) peripheral site and inhibits enzyme activity with a novel higher order concentration dependence [J] . Rosenberry Terrone L., Martin Patricia K., Nix A. Jeremy, Chemico-biological interactions . 2016,第Pta2期

机译：Hopeahainol A在乙酰胆碱酯酶（AChE）外围位点可逆结合，并以新颖的高阶浓度依赖性抑制酶活性
3. Protective effect of hopeahainol A, a novel acetylcholinesterase inhibitor, on hydrogen peroxide-induced injury in PC12 cells [J] . Da Hua Shi, Jun Hua Wu, Hui Ming Ge, Environmental toxicology and pharmacology . 2009,第1期

机译：新型乙酰胆碱酯酶抑制剂hopehahainol A对过氧化氢诱导的PC12细胞损伤的保护作用
4. Comparison Accuracy of Multi-Layer Perceptron and DNN in QSAR Classification for Acetylcholinesterase Inhibitors [C] . Mushliha, Alhadi Bustamam, Arry Yanuar, International Conference on Artificial Intelligence and Mechatronics Systems . 2021

机译：乙酰胆碱酯酶抑制剂QSAR分类中多层Perceptron和DNN的比较精度
5. Synthesis and biochemical evaluation of multifunctional acetylcholinesterase inhibitor hybrids for treatment of Alzheimer's disease. [D] . Eckroat, Todd J. 2014

机译：多功能乙酰胆碱酯酶抑制剂杂种的合成及其生化评估，用于治疗阿尔茨海默氏病。
6. Hopeahainol A binds reversibly at the acetylcholinesterase (AChE) peripheral site and inhibits enzyme activity with a novel higher order concentration dependence [O] . Terrone L. Rosenberry, Patricia K. Martin, A. Jeremy Nix, -1

机译：Hopeahainol A可逆结合在乙酰胆碱酯酶（AChE）外围位点并抑制酶活性具有新型的高阶浓度依赖性
7. Hopeahainol A binds reversibly at the acetylcholinesterase (AChE) peripheral site and inhibits enzyme activity with a novel higher order concentration dependence [O] . Terrone L. Rosenberry, Patricia K. Martin, A. Jeremy Nix, 2016

机译：Hopeahainol A可逆地在乙酰胆碱酯酶（ACHE）外周位点上结合，并抑制具有新颖性更高级浓度依赖性的酶活性
8. Reversal of Acetylcholinesterase Inhibitor Toxicity In Vivo by Inhibitors of Choline Transport. [R] . Freeman, J. J., Kosh, J. W. 1983

机译：胆碱转运抑制剂逆转乙酰胆碱酯酶抑制剂的体内毒性。

Hopeahainol A: An acetylcholinesterase inhibitor from Hopea hainanensis

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