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首页> 外文期刊>Urology >Efficacy of Gabapentin for Prevention of Postoperative Catheter-related Bladder Discomfort in Patients Undergoing Transurethral Resection of Bladder Tumor
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Efficacy of Gabapentin for Prevention of Postoperative Catheter-related Bladder Discomfort in Patients Undergoing Transurethral Resection of Bladder Tumor

机译：加巴喷丁预防膀胱肿瘤经尿道切除术后患者导管相关性膀胱不适的疗效

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摘要

OBJECTIVE: To evaluate the effect of 600 mg and 1200 mg oral gabapentin pretreatment for the prevention of postoperative catheter-related bladder discomfort (CRBD) in patients undergoing catheter-ization after transurethral resection of bladder tumor (TURBT).MATERIALS AND METHODS: One hundred adult patients undergoing elective TURBT under spinal anesthesia were randomly allocated into 3 groups. Group I patients received placebo, group II patients received 600 mg gabapentin, and group III patients received 1200 mg gabapentin 1 hour before surgery. Lumber subarachnoid block was administered with 2.5 mL 0.5% hyperbaric bupivacaine. The patients were observed for the incidence and severity of CRBD in the postoperative period.RESULTS:The incidence of CRBD was 90% in group I, 66% in group II, and 26% in group III. The incidence of bladder discomfort was significantly low in group III at all time points compared with group I and at 4, 6, 12, and 24 hours compared with group II. The severity of CRBD was also less in group II and III patients compared with group I. Fifteen patients in group I developed moderate discomfort, whereas 1 patient in group II and none in group III. None of the patient receiving gabapentin had severe discomfort. The duration and level of sensory and motor block was comparable among groups. One patient in group II and 2 patients in group III were complained of dizziness in postoperative period.CONCLUSION:Gabapentin 1200 mg administered before surgery is more effective than gabapentin 600 mg in decreasing the incidence of postoperative CRBD.
机译：目的：评价600 mg和1200 mg口服加巴喷丁预处理对经尿道膀胱肿瘤切除术（TURBT）进行导管插入术的患者术后导管相关性膀胱不适（CRBD）的预防作用。材料与方法：一百例接受脊髓麻醉的择期TURBT的成年患者被随机分为3组。第一组患者在手术前1小时接受安慰剂，第二组患者接受600 mg加巴喷丁，第三组患者接受1200 mg加巴喷丁。木材蛛网膜下腔阻滞给予2.5 mL 0.5％高压布比卡因。结果：术后I组CRBD的发生率和严重程度。结果：I组CRBD的发生率为90％，II组为66％，III组为26％。与I组相比，III组在所有时间点的膀胱不适发生率均显着较低，与II组相比，在4、6、12和24小时，膀胱不适的发生率均显着降低。与第一组相比，第二和第三组患者的CRBD严重程度也更低。第一组中有15名患者出现中度不适，第二组中有1名患者，第三组中无。加巴喷丁的患者均未出现严重不适。感觉和运动阻滞的持续时间和水平在各组之间相当。结论：术前给予1200 mg加巴喷丁比600 mg加巴喷丁对降低术后CRBD的发生率更为有效。

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