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首页> 外文期刊>Urology >Influence of the method of intracavernous injection on penile rigidity: a possible pharmacokinetic explanation.
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Influence of the method of intracavernous injection on penile rigidity: a possible pharmacokinetic explanation.

机译：腔内注射方法对阴茎硬度的影响：可能的药代动力学解释。

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OBJECTIVES: To study whether the method of intracavernous injection of vasodilators has an effect on the clinical outcome and to explain the mechanism of possible influence. METHODS: In an open clinical study, penile rigidity after bolus injection was compared with rigidity after slow injection in 52 self-injecting, impotent patients. In 35 volunteers, venous plasma levels of intracavernosally injected drugs were followed under different injection conditions: slow injection of undiluted drug, slow injection of diluted drug, bolus injection, use of a tourniquet, or slow injection followed by squeeze of the corpora. RESULTS: Of the 52 patients, 28 reported better penile rigidity after a bolus injection than after slow injection of vasodilators. The other 24 reported no difference in rigidity. Systemic side effects did not occur, but 4 patients reported local pain after bolus injection. In the 35 volunteers, the lowest plasma levels were observed when a tourniquet was used or when a bolus injection was performed; the quickest transfer was observed after a slow injection of a low volume of the drug. CONCLUSIONS: Better rigidity was observed after bolus injection in a majority of the patients using the same dose of vasodilators. This could be due to the pharmacokinetic phenomenon of a slower drug transfer to the systemic circulatory system after a bolus than after a slow injection.
机译：目的：研究腔内注射血管扩张剂的方法是否对临床疗效有影响，并解释其可能的作用机理。方法：在一项公开的临床研究中，比较了52例自我注射无能的患者推注注射后的阴茎刚度与缓慢注射后的阴茎刚度。在35名志愿者中，在不同的注射条件下跟踪了海绵体内注射药物的静脉血浆水平：缓慢注射未稀释的药物，缓慢注射稀释的药物，推注注射，使用止血带或缓慢注射，然后挤压主体。结果：在52例患者中，有28例报告了大剂量注射后的阴茎刚度好于缓慢注射血管扩张剂后的阴茎刚度。另外24个报告刚性没有差异。没有发生全身性副作用，但有4例患者在推注药丸后报告局部疼痛。在35名志愿者中，当使用止血带或推注时，血浆水平最低。在缓慢注入少量药物后，观察到最快的转移。结论：在使用相同剂量的血管扩张剂的大多数患者中，推注后观察到更好的刚性。这可能是由于推注后比缓慢注射后药物向全身循环系统的转移更慢的药代动力学现象。

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