• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Chemistry: A European journal >Low-Molecular-Weight Dendrons for DNA Binding and Release by Reduction-Triggered Degradation of Multivalent Interactions
【24h】

Low-Molecular-Weight Dendrons for DNA Binding and Release by Reduction-Triggered Degradation of Multivalent Interactions

机译：低分子树枝状分子通过多价相互作用的降低触发降解作用进行DNA结合和释放

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Nature has developed a vast repository of responsive molecular machines to carry out biological processes.[1, 2] For example,viruses are able to encapsulate and release their genetic contents in highly controlled manner. The development of simple synthetic compounds that can mimic these processes by packing genetic material into nanoscale objects is of paramount importance for many advanced biotechnological applications, especially gene delivery[3] and DNAbased materials.[4, 5] Compounds that can release their cargo in a reductive environment are particularly interesting in non-viral gene delivery,[6] where intracellular reduction can trigger the release of DNA.[7] Efficient DNA release can be considered as an important prerequisite for effective transfection. Much attention in this research field has been focused on reducible lipids,[8] high molecular weight reductively cleavable polycations[9–12] and thiolated polyethylenimine (PEI).[13, 14] However, relatively low-molecular-weight compounds that could bind DNA with high affinity and release it in a controlled manner have remained largely unexplored. Dendritic molecules are particularly useful as binding agents because of the multivalency effect: dendrons can have multiple densely packed surface groups that can offer multiple simultaneous interactions leading to enhanced binding.[15–17]
机译：大自然已经开发了一个庞大的响应分子机器资料库来进行生物过程。[1，2]例如，病毒能够以高度受控的方式封装和释放其遗传成分。通过将遗传物质包装到纳米尺度的物体中，可以模拟这些过程的简单合成化合物的开发对于许多先进的生物技术应用尤其重要，尤其是基因传递[3]和基于DNA的材料。[4，5]可以在体内释放货物的化合物。在非病毒基因传递中，还原性环境尤为有趣，[6]细胞内还原可触发DNA的释放。[7]高效的DNA释放可被视为有效转染的重要先决条件。在该研究领域中，注意力集中在可还原脂质，[8]高分子量可还原裂解的聚阳离子[9-12]和硫醇化聚乙烯亚胺（PEI）上。[13，14]但是，相对低分子量的化合物可以以高亲和力结合DNA并以受控方式释放DNA的方法至今仍未开发。由于多价效应，树突分子特别可用作结合剂：树突可以具有多个紧密堆积的表面基团，这些表面基团可以提供多个同时相互作用，从而增强结合。[15-17]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号