...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Urology >Impact of the percentage of positive biopsy cores on the further stratification of primary grade 3 and grade 4 Gleason score 7 tumors in radical prostatectomy patients.
【24h】

Impact of the percentage of positive biopsy cores on the further stratification of primary grade 3 and grade 4 Gleason score 7 tumors in radical prostatectomy patients.

机译：活检核心的百分比对前列腺癌根治术患者原发性3级和4级Gleason评分7肿瘤进一步分层的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVES: To examine whether the percentage of core biopsies positive can further stratify Gleason score 7 patients with primary Gleason grade into precise prognostic groups. METHODS: Between 1991 and 1999, 379 radical prostatectomy patients were found to have pathologic Gleason 7 tumors. The patients were divided into primary grade 3 or 4. Percentage positive was calculated by dividing the number of positive core biopsies by the total number of cores. RESULTS: In the cohort, 290 tumors were primary grade 3, and 89 were primary grade 4. On univariate analysis patients with primary grade 3 tumors had a significant prostate-specific antigen (PSA) progression-free survival advantage over grade 4 patients. When separated according to percentage of core biopsies positive, statistical analysis revealed significantly better 60-month actuarial PSA progression-free survival for patients with grade 3 and grade 4 and less than 50% core biopsies positive as compared with grade 3 and grade 4 and 50% or more core biopsies positive (85%, 85%, 61%, and 33%, respectively). Furthermore, multivariate analysis demonstrated that primary grade did not have an independent impact on biochemical progression-free survival. However, on subset analysis, among patients with 50% or more biopsy cores positive, primary Gleason grade was indeed found to have a significant, independent impact. CONCLUSIONS: In the present study Gleason 7 patients with primary grade 4 tumors and less than 50% of biopsy cores positive had an excellent prognosis after radical prostatectomy. Our data suggest that among Gleason 7 patients, the percentage of positive biopsies is a stronger predictor of biochemical progression-free survival than primary Gleason grade.
机译：目的：检查核心活检的阳性率是否可以将Gleason评分为7的原发性Gleason分级患者进一步分为准确的预后组。方法：1991年至1999年，发现379例前列腺癌根治术患者患有病理性Gleason 7肿瘤。将患者分为3级或4级。阳性率是用核心活检阳性数除以核心总数来计算的。结果：在该队列中，290例肿瘤为原发性3级，89例为原发性4级。单因素分析显示，原发性3级肿瘤患者比4级患者具有明显的前列腺特异性抗原（PSA）无进展生存优势。根据核心活检阳性百分比进行分离时，统计分析显示，与3级，4和50级相比，3级和4级且核心活检阳性率低于50％的患者60个月精算PSA无进展生存期明显更好％或更多的核心活检阳性（分别为85％，85％，61％和33％）。此外，多变量分析表明，小学等级对生化无进展生存期没有独立影响。但是，在子集分析中，活检核心阳性率为50％或更高的患者中，确实发现原发性Gleason评分具有显着的独立影响。结论：在本研究中，Gleason 7例原发性4级肿瘤且活检芯少于50％的患者在前列腺癌根治术后的预后良好。我们的数据表明，在格里森7例患者中，活检阳性率比原先的格里森分级更能预测生化无进展生存。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号