A simple primary amine thiourea catalyzed highly enantioselective conjugate addition of α,α-disubStituted aldehydes to maleimides

Xue F.; Liu L.; Zhang S.; Duan W.; Wang W.

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A simple primary amine thiourea catalyzed highly enantioselective conjugate addition of α,α-disubStituted aldehydes to maleimides

机译：简单的伯胺硫脲催化α，α-二取代醛向马来酰亚胺的高对映选择性共轭加成

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(Figure Presented) Branch point: A simple primary amine thiourea catalyzed highly enantioselective conjugate addition of α,α-disubstituted aldehydes to maleimides has been developed. The biologically useful chiral disubstituted α-branched succinimides are attained with the generation of two contiguous quaternary and/or tertiary stereogenic centers in one step with excellent enantioselectivities and in high yields under mild reaction conditions (see scheme).

机译：（显示的图）分支点：已经开发了一种简单的伯胺硫脲催化的α，α-二取代醛向马来酰亚胺的高对映选择性共轭加成反应。具有生物学上有用的手性二取代的α-支化琥珀酰亚胺是通过在温和的反应条件下，以极好的对映选择性和高收率一步生成两个连续的季和/或叔立体异构中心而获得的（参见方案）。

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《Chemistry: A European journal》 |2010年第27期|共4页
作者
Xue F.; Liu L.; Zhang S.; Duan W.; Wang W.;
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正文语种 eng
中图分类应用化学;
关键词
Aldehydes; Maleimides; Michael addition; Organocatalysis;

机译：醛;马来酰亚胺;迈克尔加成;有机催化;

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1. A simple primary amine thiourea catalyzed highly enantioselective conjugate addition of α,α-disubStituted aldehydes to maleimides [J] . Xue F., Liu L., Zhang S., Chemistry: A European journal . 2010,第27期

机译：简单的伯胺硫脲催化α，α-二取代醛向马来酰亚胺的高对映选择性共轭加成
2. A highly efficient asymmetric Michael addition of α,α-disubstituted aldehydes to maleimides catalyzed by primary amine thiourea salt [J] . Feng Yu, Zhichao Jin, Huicai Huang, Organic & biomolecular chemistry . 2010,第20期

机译：伯胺硫脲盐催化的α，α-二取代醛向马来酰亚胺的高效不对称迈克尔加成反应
3. Highly enantioselective Michael addition of alpha,alpha-disubstituted aldehydes to maleimides catalyzed by new primary amine-squaramide bifunctional organocatalysts [J] . Ma Zhi-wei, Liu Xiao-feng, Liu Jun-tao, Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2017,第48期

机译：高映选择性迈克尔加入α-二取代的醛与新的伯胺 - 鳞甲酰胺双官能有机催化剂催化的马来酰亚胺
4. Chiral Amine-Catalyzed Asymmetric Conjugate Addition of Aldehydes to α-Phenylselenoenones as Z-Allylating Agents [C] . Chihiro Homma, Hiroki Maruyama, Taichi Kano 日本化学会春季年会講演予稿集 . 2018

机译：作为Z-烯丙基化剂的手性胺催化的不对称缀合物加入α-苯基硒烯酮的醛
5. I. Highly regioselective diastereoselective directed hydroformylation of allyl ethers. II. Highly practical and enantioselective ligands for copper-catalyzed conjugate addition. [D] . Krauss, Isaac Jonathan. 2003

机译：I.烯丙基醚的高度区域选择性非对映选择性定向加氢甲酰化。二。用于铜催化共轭加成的高度实用和对映选择性配体。
6. Enantioselective Michael Addition of Aldehydes to Maleimides Organocatalyzed by a Chiral Primary Amine-Salicylamide [O] . Alejandro Torregrosa-Chinillach, Adrien Moragues, Haritz Pérez-Furundarena, 2018

机译：手性伯胺-水杨酰胺对有机化合物催化的马来酰亚胺中醛的对映选择性迈克尔加成反应
7. A Chiral Primary Amine-Thiourea Catalyst for the Highly Enantioselective Direct Conjugate Addition of α,α-Disubstituted Aldehydes to Nitroalkenes [O] . Mathieu P. Lalonde, Yonggang Chen, Eric N. Jacobsen 2015

机译：一种手性伯胺 - 硫脲催化剂，用于α，α-二取代醛与硝基烯烃的高对映选择性直接共轭加成

A simple primary amine thiourea catalyzed highly enantioselective conjugate addition of α,α-disubStituted aldehydes to maleimides

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