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首页> 外文期刊>Peritoneal dialysis international: Journal of the International Society for Peritoneal Dialysis >Effect of peritoneal dialysis on peritoneal cell biology: peritoneal fibroblasts.
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Effect of peritoneal dialysis on peritoneal cell biology: peritoneal fibroblasts.

机译：腹膜透析对腹膜细胞生物学的影响：腹膜成纤维细胞。

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摘要

Despite the fact that the characterization of human peritoneal fibroblast biology and function is, at present, only in its early stages, the evidence available to date clearly indicates that direct interactions of peritoneal macrophages and fibroblasts may significantly contribute to the production of chemotactic and pro-inflammatory factors within the peritoneal cavity. In vitro models studying human peritoneal fibroblasts in two-dimensional or three-dimensional culture systems will further contribute to our understanding of the regulatory processes involved in peritoneal inflammation and fibrosis. In addition, the development of novel peritoneal dialysis solutions will have not only to examine the effect of these solutions on immune cells and the peritoneal mesothelium, but also to take into consideration the potential impact on peritoneal fibroblast function.
机译：尽管目前人类腹膜成纤维细胞的生物学特性和功能只是在其早期阶段，但迄今为止可用的证据清楚地表明，腹膜巨噬细胞与成纤维细胞的直接相互作用可能显着促进了趋化性和促成纤维细胞生成腹膜腔内的炎症因子。在二维或三维培养系统中研究人类腹膜成纤维细胞的体外模型将进一步有助于我们对涉及腹膜炎症和纤维化的调节过程的理解。另外，新型腹膜透析溶液的开发将不仅要检查这些溶液对免疫细胞和腹膜间皮细胞的作用，而且还要考虑对腹膜成纤维细胞功能的潜在影响。

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