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首页> 外文期刊>Peritoneal dialysis international: Journal of the International Society for Peritoneal Dialysis >Blood flow does not limit peritoneal transport.
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Blood flow does not limit peritoneal transport.

机译：血流不限制腹膜运输。

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OBJECTIVE: We investigated the assumption that blood flow to the microvessels underlying the peritoneum does not limit solute or water exchange between the blood and the dialysis fluid. DESIGN: Small plastic chambers were affixed to the serosal side of the liver, cecum, stomach, and abdominal wall of anesthetized rats. Solutions that contained labeled solutes or that were made hypertonic were placed into the chambers, which restricted the area of transfer across the tissue to the base of the chamber and which permitted calculation of mass or water transfer rates on the basis of area. The local blood flow was monitored continuously with a laser Doppler flowmeter during three periods of observation: control, after 50%-70% reduction of the blood flow, and postmortem. RESULTS: Urea transfer across all serosa, except for the liver, showed no difference in mean mass transfer coefficient (cm/min) between control (0.0038-0.0046) and after 70% flow reduction (0.0037-0.0040), but demonstrated a significant decrease with blood flow equal to zero (0.0020). These tissues demonstrated small but insignificant decreases in osmotic water flow into the chamber (0.7-0.9 microL/min/cm2 under control conditions versus 0.4-0.7 microL/min/cm2 with reduced blood flow). The liver demonstrated limitations in water and solute transport with a 70% decrease in blood flow. CONCLUSION: Because the liver makes up a small part of the peritoneal area, we conclude that large drops in blood flow do not limit overall solute or water transfer across the peritoneum during dialysis, and therefore acute peritoneal dialysis may be an appropriate modality for ICU patients in shock and renal failure.
机译：目的：我们研究了这样一种假设，即流向腹膜下的微血管的血液不会限制血液和透析液之间的溶质或水交换。设计：将小塑料腔室固定在麻醉大鼠的肝脏，盲肠，胃和腹壁的浆膜侧。将包含标记溶质或制成高渗溶液的溶液放入腔室中，该溶液限制了从组织到腔室底部的转移面积，并允许根据面积计算质量或水的转移速率。在以下三个观察阶段中，用激光多普勒流量计连续监测局部血流量：在血流量减少50％-70％之后进行对照，然后进行验尸。结果：除肝脏外，尿素在所有浆膜中的转移均未显示，对照组（0.0038-0.0046）与流量减少70％（0.0037-0.0040）后的平均传质系数（cm / min）无差异，但显示出明显降低血液流量等于零（0.0020）。这些组织显示出进入腔室的渗透水量有少量但微不足道的下降（在对照条件下为0.7-0.9 microL / min / cm2，而在血液流量减少的情况下为0.4-0.7 microL / min / cm2）。肝脏在水和溶质运输方面表现出局限性，血流减少了70％。结论：由于肝脏仅占腹膜区域的一小部分，因此我们得出结论，在透析期间，大流量血流不会限制整体溶质或水在整个腹膜上的转移，因此急性腹膜透析对于ICU患者可能是一种合适的方式在休克和肾衰竭中。

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