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首页> 外文期刊>Urologic oncology >Nanoparticles for drug delivery in cancer treatment.
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Nanoparticles for drug delivery in cancer treatment.

机译：用于癌症治疗中药物递送的纳米颗粒。

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Nanoparticles (size in nanometer range) provide a new mode of cancer drug delivery functioning as a carrier for entry through fenestrations in tumor vasculature allowing direct cell access. These particles allow exquisite modification for binding to cancer cell membranes, the microenvironment, or to cytoplasmic or nuclear receptor sites. This results in delivery of high drug concentrations to the targeted cancer cell, with reduced toxicity of normal tissue. Several such engineered drugs are in clinical practice, including liposomal doxorubicin and albumin conjugate paclitaxel. The carrier mediated paclitaxel has already shown significant efficacy in taxane resistant cancers, an approach highly relevant in prostate cancer, where taxanes are the treatment of choice. Other modifications including transferrin receptor and folate receptor targeted drug delivery molecules are in study. This new technology provides many exciting therapeutic approaches for targeted high concentration drug delivery to cancer cells with reduced injury of normal cells.
机译：纳米粒子（尺寸在纳米范围内）提供了一种新的癌症药物递送模式，可作为通过肿瘤脉管系统中的窗孔进入的载体，从而可以直接进入细胞。这些颗粒可以进行精细修饰，以结合至癌细胞膜，微环境或细胞质或核受体部位。这导致将高药物浓度递送至靶癌细胞，同时降低了正常组织的毒性。几种这样的工程药物正在临床实践中，包括脂质体阿霉素和白蛋白结合紫杉醇。载体介导的紫杉醇已经在紫杉烷类耐药性癌症中显示出显着功效，而紫杉烷类药物是治疗前列腺癌的重要方法。其他修饰包括转铁蛋白受体和叶酸受体靶向的药物传递分子正在研究中。这项新技术提供了许多激动人心的治疗方法，可将高浓度药物靶向靶向地输送到癌细胞，同时减少正常细胞的损伤。

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