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首页> 外文期刊>Biochimica et Biophysica Acta. General Subjects >Niacin improves renal lipid metabolism and slows progression in chronic kidney disease.
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Niacin improves renal lipid metabolism and slows progression in chronic kidney disease.

机译：烟酸改善慢性肾脏疾病中的肾脏脂质代谢并减缓其进展。

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BACKGROUND: Mounting evidence points to lipid accumulation in the diseased kidney and its contribution to progression of nephropathy. We recently found heavy lipid accumulation and marked dysregulation of lipid metabolism in the remnant kidneys of rats with chronic renal failure (CRF). Present study sought to determine efficacy of niacin supplementation on renal tissue lipid metabolism in CRF. METHODS: Kidney function, lipid content, and expression of molecules involved in cholesterol and fatty acid metabolism were determined in untreated CRF (5/6 nephrectomized), niacin-treated CRF (50 mg/kg/day in drinking water for 12 weeks) and control rats. RESULTS: CRF resulted in hypertension, proteinuria, renal tissue lipid accumulation, up-regulation of scavenger receptor A1 (SR-A1), acyl-CoA cholesterol acyltransferase-1 (ACAT1), carbohydrate-responsive element binding protein (ChREBP), fatty acid synthase (FAS), acyl-CoA carboxylase (ACC), liver X receptor (LXR), ATP binding cassette (ABC) A-1, ABCG-1, and SR-B1 and down-regulation of sterol responsive element binding protein-1 (SREBP-1), SREBP-2, HMG-CoA reductase, PPAR-alpha, fatty acid binding protein (L-FABP), and CPT1A. Niacin therapy attenuated hypertension, proteinuria, and tubulo-interstitial injury, reduced renal tissue lipids, CD36, ChREBP, LXR, ABCA-1, ABCG-1, and SR-B1 abundance and raised PPAR-alpha and L-FABP. CONCLUSIONS AND GENERAL SIGNIFICANCE: Niacin administration improves renal tissue lipid metabolism and renal function and structure in experimental CRF.
机译：背景：越来越多的证据表明，患病肾脏中的脂质蓄积及其对肾病进展的贡献。我们最近发现，慢性肾功能衰竭（CRF）大鼠的残余肾脏中大量脂质积累和脂质代谢显着失调。本研究试图确定烟酸补充对CRF中肾组织脂质代谢的功效。方法：测定未经治疗的CRF（5/6肾切除），烟酸治疗的CRF（50 mg / kg / day，在饮用水中持续12周）的肾脏功能，脂质含量以及参与胆固醇和脂肪酸代谢的分子表达。对照大鼠。结果：CRF导致高血压，蛋白尿，肾脏组织脂质蓄积，清除受体A1（SR-A1），酰基辅酶A胆固醇酰基转移酶-1（ACAT1），糖皮质激素敏感结合蛋白（ChREBP），脂肪酸的上调合酶（FAS），酰基辅酶A羧化酶（ACC），肝X受体（LXR），ATP结合盒（ABC）A-1，ABCG-1和SR-B1以及下调固醇反应元件结合蛋白-1 （SREBP-1），SREBP-2，HMG-CoA还原酶，PPAR-α，脂肪酸结合蛋白（L-FABP）和CPT1A。烟酸疗法可减轻高血压，蛋白尿和肾小管间质损伤，减少肾组织脂质，CD36，ChREBP，LXR，ABCA-1，ABCG-1和SR-B1丰度，并提高PPAR-α和L-FABP。结论和一般意义：烟酸给药可改善实验性CRF中的肾脏组织脂质代谢以及肾脏功能和结构。

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