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首页> 外文期刊>Peritoneal dialysis international: Journal of the International Society for Peritoneal Dialysis >Lower education level is a major risk factor for peritonitis incidence in chronic peritoneal dialysis patients: A retrospective cohort study with 12-year follow-up
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Lower education level is a major risk factor for peritonitis incidence in chronic peritoneal dialysis patients: A retrospective cohort study with 12-year follow-up

机译：较低的教育水平是慢性腹膜透析患者腹膜炎发生率的主要危险因素：一项为期12年的回顾性队列研究

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Background: Peritoneal dialysis (PD)-related peritonitis remains an important complication in PD patients, potentially causing technique failure and influencing patient outcome. To date, no comprehensive study in the Taiwanese PD population has used a time-dependent statistical method to analyze the factors associated with PD-related peritonitis. Methods: Our single-center retrospective cohort study, conducted in southern Taiwan between February 1999 and July 2010, used time-dependent statistical methods to analyze the factors associated with PD-related peritonitis. Results: The study recruited 404 PD patients for analysis, 150 of whom experienced at least 1 episode of peritonitis during the follow-up period. The incidence rate of peritonitis was highest during the first 6 months after PD start. A comparison of patients in the two groups (peritonitis vs null-peritonitis) by univariate analysis showed that the peritonitis group included fewer men (p= 0.048) and more patients of older age (≥65 years, p= 0.049). In addition, patients who had never received compulsory education showed a statistically higher incidence of PD-related peritonitis in the univariate analysis (p= 0.04). A proportional hazards model identified education level (less than elementary school vs any higher education level) as having an independent association with PD-related peritonitis [hazard ratio (HR): 1.45; 95% confidence interval (CI): 1.01 to 2.06; p= 0.045). Comorbidities measured using the Charlson comorbidity index (score >2 vs ≤2) showed borderline statistical significance (HR: 1.44; 95% CI: 1.00 to 2.13; p= 0.053). Conclusions: A lower education level is a major risk factor for PD-related peritonitis independent of age, sex, hypoalbuminemia, and comorbidities. Our study emphasizes that a comprehensive PD education program is crucial for PD patients with a lower education level.
机译：背景：腹膜透析（PD）相关的腹膜炎仍然是PD患者的重要并发症，可能导致技术失败并影响患者预后。迄今为止，台湾PD人群中尚无全面的研究使用时间依赖性统计方法来分析与PD相关性腹膜炎相关的因素。方法：我们于1999年2月至2010年7月在台湾南部进行的单中心回顾性队列研究使用了时变统计方法来分析与PD相关性腹膜炎相关的因素。结果：该研究招募了404名PD患者进行分析，其中150名在随访期间经历了至少1次腹膜炎发作。腹膜透析开始后的前6个月，腹膜炎的发生率最高。通过单因素分析对两组患者（腹膜炎与无效腹膜炎）进行比较后发现，腹膜炎组的男性人数较少（p = 0.048），而年龄较大的患者（≥65岁，p = 0.049）。此外，从未接受过义务教育的患者在单因素分析中显示PD相关性腹膜炎的发生率在统计学上较高（p = 0.04）。比例风险模型确定教育水平（低于小学水平与任何高等教育水平）与PD相关性腹膜炎具有独立关联[风险比（HR）：1.45; 95％置信区间（CI）：1.01至2.06; p = 0.045）。使用查尔森合并症指数测量的合并症（得分> 2 vs≤2）显示出统计学上的显着性差异（HR：1.44; 95％CI：1.00至2.13; p = 0.053）。结论：较低的教育水平是与PD相关的腹膜炎的主要危险因素，与年龄，性别，低白蛋白血症和合并症无关。我们的研究强调，全面的PD教育计划对于文化程度较低的PD患者至关重要。

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