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首页> 外文期刊>Chemistry: A European journal >An Ir-Pt catalyst for the multistep preparation of functionalized indoles from the reaction of amino alcohols and alkynyl alcohols
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An Ir-Pt catalyst for the multistep preparation of functionalized indoles from the reaction of amino alcohols and alkynyl alcohols

机译：Ir-Pt催化剂，用于从氨基醇与炔醇的反应分步制备官能化的吲哚

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The 1,2,4-trimethyltriazolylidene (ditz) ligand allows the preparation of homo- and heterodimetallic complexes of Pt_2 and Ir-Pt. These two complexes have been characterized by means of spectroscopic and diffractommetric techniques. The catalytic activity of these complexes, together with that of other Pt-based compounds, has been explored in the cyclization-addition of alkynyl alcohols and indoles. The Ir-Pt complex [{PtI_2(py)}(μ- ditz){IrI_2(Cp*)}] (py=pyridine; Cp*= pentamethylcyclopentadienyl) allows the combination of an iridium-mediated oxidative cyclization of 2-(ortho-aminophenyl)ethanol to form indoles, with a further step employing a Pt-based multistep reaction that functionalizes indoles. Our results show that the Ir-Pt complex is a very active catalyst in this new multistep preparation of functionalized indoles from the reaction of an amino alcohol with alkynyl alcohols. Three in one: A heterodimetallic complex of Ir-Pt (see graphic) with a triazolyldiylidene linker has been obtained and fully characterized. The complex brings together some of the catalytic properties typically shown by Ir and Pt catalysts. A multistep reaction employing the Ir-mediated oxidative cyclization of 2-(ortho-aminophenyl)ethanol and the Pt-catalyzed cyclization-addition of alkynyl alcohols to indoles is reported.
机译：1,2,4-三甲基三唑基（ditz）配体可以制备Pt_2和Ir-Pt的均二金属和异二金属配合物。这两种配合物已经通过光谱和衍射技术表征。这些配合物以及其他基于Pt的化合物的催化活性已在炔醇和吲哚的环化加成中得到了探索。 Ir-Pt络合物[{PtI_2（py）}（μ-ditz）{IrI_2（Cp *）}]（py =吡啶; Cp * =五甲基环戊二烯基）可以结合铱介导的2-（邻位）氧化环化反应-氨基苯基）乙醇形成吲哚，进一步的步骤采用官能化吲哚的基于Pt的多步反应。我们的结果表明，在氨基醇与炔醇反应的这种新的多步官能化吲哚制备中，Ir-Pt络合物是非常活泼的催化剂。三合一：已获得Ir-Pt的杂二金属配合物（见图），并已进行了充分表征。该络合物汇集了通常由Ir和Pt催化剂显示的某些催化性能。报道了使用Ir介导的2-（邻氨基苯基）乙醇的氧化环化和Pt催化的炔醇向吲哚的环化加成的多步反应。

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