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首页> 外文期刊>Chemistry: A European journal >Surface modification of polymeric micelles by strain-promoted alkyne-azide cycloadditions
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Surface modification of polymeric micelles by strain-promoted alkyne-azide cycloadditions

机译：应变促进炔-叠氮化物环加成反应对聚合物胶束进行表面改性

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摘要

Organomicelles modified by surface dibenzylcyclooctyne moieties can conveniently be functionalized by strain-promoted alkyne-azide cycloadditions. The ligation approach is highly efficient, does not require toxic reagents and is compatible with a wide variety of functional modules. Interactions of proteins with surface ligands of the micelles have been studied by AFM, which revealed that it leads to disassembly of the particles thereby providing a mechanism for triggered drug release. Click to deliver: Organomicelles modified by surface dibenzylcyclooctyne moieties can conveniently be functionalized by strain-promoted alkyne-azide cycloadditions. The ligation approach is highly efficient, does not require toxic reagents and is compatible with a wide variety of functional modules. Interactions of proteins with surface ligands of the micelles have been studied by AFM, which revealed that it leads to disassembly of the particles thereby providing a mechanism for triggered drug release.
机译：表面二苄基环辛炔基部分修饰的有机胶束可通过菌株促进的炔-叠氮化物环加成而方便地官能化。连接方法高效，不需要毒性试剂，并且与多种功能模块兼容。蛋白质与胶束表面配体的相互作用已经通过原子力显微镜研究，结果表明它导致颗粒的分解，从而提供了触发药物释放的机制。点击交付：表面二苄基环辛炔基部分修饰的有机细胞可以通过应变促进的炔-叠氮化物环加成反应方便地功能化。连接方法高效，不需要毒性试剂，并且与多种功能模块兼容。蛋白质与胶束表面配体的相互作用已经通过原子力显微镜研究，结果表明它导致颗粒的分解，从而提供了触发药物释放的机制。

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