Artificial transcription factors which mediate double-strand DNA Cleavage

Li C.; Du C.; Tian H.; Jiang C.; Du M.; Liu Y.; Qiao R.-Z.; Jia Y.-X.; Zhao Y.-F.

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Artificial transcription factors which mediate double-strand DNA Cleavage

机译：介导双链DNA切割的人工转录因子

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A new family of artificial transcription factor (ATF)-based conjugates have been designed and synthesized as potent chemical nucleases. Polyamides as the important and efficient ATFs were used to modify and activate several anchor compounds. The results demonstrate that the resulting conjugates remarkably promote the rate accelerations and non-random double-strnd DNA cleavage activity. Interestingly, the cleavage activity of both the hydrolytic and oxidative agents was promoted efficiently through the modification of the ATFs.

机译：一种新型的基于人工转录因子（ATF）的结合物已经被设计并合成为有效的化学核酸酶。聚酰胺是重要且有效的ATF，用于修饰和活化几种锚固化合物。结果表明，所得的缀合物显着促进了速率加速和非随机双链DNA切割活性。有趣的是，通过修饰ATF可以有效地促进水解剂和氧化剂的裂解活性。

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《Chemistry: A European journal》 |2010年第43期|共6页
作者
Li C.; Du C.; Tian H.; Jiang C.; Du M.; Liu Y.; Qiao R.-Z.; Jia Y.-X.; Zhao Y.-F.;
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正文语种 eng
中图分类应用化学;
关键词
artificial transcription factors; DNA binding; DNA cleavage; double-strand cleavage; polyamide;

机译：人工转录因子;DNA结合;DNA切割;双链切割;聚酰胺;

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专利

1. Artificial transcription factors which mediate double-strand DNA Cleavage [J] . Li C., Du C., Tian H., Chemistry: A European journal . 2010,第43期

机译：介导双链DNA切割的人工转录因子
2. Efficient double-strand cleavage of DNA mediated by Zn(ii)-based artificial nucleases [J] . Qian J., Wang L., Gu W., Dalton transactions: An international journal of inorganic chemistry . 2011,第20期

机译：基于锌（ii）的人工核酸酶介导的DNA的有效双链切割。
3. Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors [J] . Pessina Fabio, Giavazzi Fabio, Yin Yandong, Nature cell biology . 2019,第10期

机译：DNA双链中的功能转录启动子断裂介导RNA驱动的相分离损伤响应因子
4. FIAT, the factor-inhibiting ATF4-mediated transcription, also represses the transcriptional activity of the bZIP factor FRA-1 [C] . Rene St-Arnaud, Vice Mandic, Bilal Elchaarani Conference on Skeletal Biology and Medicine . 2010

机译：菲亚特，抑制ATF4介导的转录，还抑制了BZIP因子FRA-1的转录活性
5. Transcription Factor Sp1 Promotes Chromatin Remodeling at DNA Double-Strand Breaks [D] . Beishline, Kate. 2013

机译：转录因子Sp1促进DNA双链断裂处的染色质重塑。
6. The peptide antibiotic microcin B17 induces double-strand cleavage of DNA mediated by E. coli DNA gyrase. [O] . J L Vizán, C Hernández-Chico, I del Castillo, 1991

机译：肽抗生素微素B17诱导大肠杆菌DNA促旋酶介导的DNA的双链切割。
7. Artificial Transcription Factors which Mediate Double-Strand DNA Cleavage [O] . Li Chao（Beijing Univ Chem Technol State Key Lab Chem Resource Engn）, Du Chao（Beijing Univ Chem Technol State Key Lab Chem Resource Engn）, Tian Hua（Beijing Univ Chem Technol State Key Lab Chem Resource Engn）, 2010

机译：人工转录因子介导双链DNA切割。

Artificial transcription factors which mediate double-strand DNA Cleavage

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