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首页> 外文期刊>Chemistry: A European journal >Photolysis and thermolysis of platinum(IV) 2,2′-bipyridine complexes lead to identical platinum(II)-DNA adducts
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Photolysis and thermolysis of platinum(IV) 2,2′-bipyridine complexes lead to identical platinum(II)-DNA adducts

机译：铂（IV）2,2'-联吡啶配合物的光解和热解可导致相同的铂（II）-DNA加合物

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摘要

Two Pt~(IV) and two Pt~(11) complexes containing a 2,2′-bipyridine ligand were treated with a short DNA oligonucleotide under light irradiation at 37 °C or in the dark at 37 and 50 °C. Photolysis and thermolysis of the Pt~(IV) complexes led to spontaneous reduction of the Pt~(IV) to the corresponding Pt~(II) complexes and to binding of Pt~(II) 2,2′-bipyridine complexes to N7 of guanine. When the reduction product was [Pt(bpy)Cl_2], formation of bis-oligonucleotide adducts was observed, whereas [Pt(bpy)(MeNH _2)Cl]~+ gave monoad- ducts, with chloride ligands substituted in both cases. Neither in the dark nor under light irradiation was the reductive elimination process of these Pt~(IV) complexes accompanied by oxidative DNA damage. This work raises the question of the stability of photoacti- vatable Pt~(IV) complexes toward moderate heating conditions.
机译：在37°C的光照下或在37和50°C的黑暗条件下，用短的DNA寡核苷酸处理了两个包含2,2'-联吡啶配体的Pt〜（IV）和两个Pt〜（11）配合物。 Pt〜（IV）配合物的光解和热解导致Pt〜（IV）自发还原为相应的Pt〜（II）配合物并导致Pt〜（II）2,2'-联吡啶配合物与N7的N7结合鸟嘌呤。当还原产物为[Pt（bpy）Cl_2]时，观察到双寡核苷酸加合物的形成，而[Pt（bpy）（MeNH _2）Cl]〜+给出单加成，在两种情况下均取代了氯配体。这些Pt〜（IV）配合物的还原消除过程在黑暗和光照射下都不会伴随着氧化性DNA损伤。这项工作提出了光活化Pt〜（IV）配合物在适度加热条件下的稳定性问题。

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