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首页> 外文期刊>Chemistry: A European journal >Novel Formulations of Vitamins and Insulin by Nanoengineering of Polyelectrolyte Multilayers around Microcrystals
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Novel Formulations of Vitamins and Insulin by Nanoengineering of Polyelectrolyte Multilayers around Microcrystals

机译：通过微晶周围的聚电解质多层纳米工程对维生素和胰岛素的新配方

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摘要

Microcapsules loaded with vitamin K_3(VK_3),biotin,or insulin were prepared by using a novel coating technology based on the layer-by-layer(LbL)deposition of oppositely charged polyelectrolytes onto microcrystal templates.This produced multilayered,polymeric shells of varying thickness around the crystalline cores.Dissolution of the core material(VK_3 with ethanol,biotin with basic solution,and insulin with acidic solution),resulted in its release through the shells.Micro-electrophoresis was employed to monitor the microcrystal coating process;confocal laser scanning microscopy (CLSM)and atomic force microscopy(AFM)were used to verify multilayer coating and the formation of hollow polymer shells following removal of the microcrystal templates.The release rates of both VK_3 and insulin decreased as the wall thickness(the number of polyelectrolyte layers deposited onto the microcrystal cores),increased.The release time could be varied by a factor of more than ten,depending on the number of polyelectrolyte layers applied.Following the addition of 70 mass % ethanol,the solubility of VK_3 increased by as much as 170-fold,resulting in an increased rate of VK_3 release.By selecting appropriate polymer materials for the shells,and by controlling the number of polyelectrolyte layers applied,shells of various thickness,stiffness,aqueous solubility,dispersibility,biocompatibility,and permeability can be constructed.
机译：采用一种新颖的包衣技术，基于将带相反电荷的聚电解质逐层（LbL）沉积在微晶模板上，从而制备了一种富含维生素K_3（VK_3），生物素或胰岛素的微囊，制成了厚度可变的多层聚合物壳核心物质（VK_3在乙醇中溶解，生物素在碱性溶液中溶解，胰岛素在酸性溶液中溶解）导致其通过壳层释放。微电泳监测微晶涂层过程;共聚焦激光扫描显微镜（CLSM）和原子力显微镜（AFM）用于验证去除微晶模板后的多层涂层和中空聚合物壳的形成.VK_3和胰岛素的释放速率均随壁厚（聚电解质层数）而降低释放时间可能会变化十倍以上，具体取决于数量在添加70质量％乙醇后，VK_3的溶解度增加了170倍，导致VK_3的释放速率增加。通过为壳选择合适的聚合物材料并控制数量根据所施加的聚电解质层，可以构建各种厚度，刚度，水溶性，分散性，生物相容性和渗透性的壳。

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