Transsialidase from Trypanosoma cruzi for Regio-and Stereoselective Synthesis of N-Acyl-Modified Sialylated Oligosaccharides and Measurement of Transfer Rates

Andreas Schroven; Sebastian Meinke; Patrick Ziegelmuller

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Transsialidase from Trypanosoma cruzi for Regio-and Stereoselective Synthesis of N-Acyl-Modified Sialylated Oligosaccharides and Measurement of Transfer Rates

机译：克氏锥虫的转唾液酸酶用于N-酰基修饰的唾液酸化寡糖的区域和立体选择性合成及转移速率的测定

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Recombinant transsialidase from Trypanosoma cruzi(TcTS)was used for the sialylation with natural and non-natural derivatives of neuraminic acid.Neu5Ac-alpha(2->3)-Gal-beta(1->6)-Glc-alpha OMe was prepared in 80% yield.Correspondingly,the modified trisaccharide derivatives Neu5Prop-alpha(2->3)-Gal-beta(1->6)-Glc-alpha OMe(32%)and Neu5Gc-alpha(2->3)-Gal-beta(1->6)-Glc-alpha OMe(Prop=propanoyl,Gc = glycolyl)were obtained in 60 % yield,respectively.

机译：使用来自克鲁氏锥虫（TcTS）的重组转唾液酸酶与神经氨酸的天然和非天然衍生物进行唾液酸化反应。制备了Neu5Ac-alpha（2-> 3）-Gal-beta（1-> 6）-Glc-alpha OMe相应地，修饰的三糖衍生物Neu5Prop-alpha（2-> 3）-Gal-beta（1-> 6）-Glc-alpha OMe（32％）和Neu5Gc-alpha（2-> 3）-分别以60％的产率获得了Gal-β（1-＞ 6）-Glc-αOMe（Prop ＝丙酰基，Gc ＝乙醇酰基）。

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《Chemistry: A European journal》 |2007年第32期|共10页
作者
Andreas Schroven; Sebastian Meinke; Patrick Ziegelmuller;
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正文语种 eng
中图分类化学;
关键词
enzyme catalysis glycosylation; neuraminic acid; sialylation; transsialidase;

机译：酶催化糖基化;神经氨酸;唾液酸化;转唾液酸酶;

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1. Transsialidase from Trypanosoma cruzi for Regio-and Stereoselective Synthesis of N-Acyl-Modified Sialylated Oligosaccharides and Measurement of Transfer Rates [J] . Andreas Schroven, Sebastian Meinke, Patrick Ziegelmuller Chemistry: A European journal . 2007,第32期

机译：克氏锥虫的转唾液酸酶用于N-酰基修饰的唾液酸化寡糖的区域和立体选择性合成及转移速率的测定
2. Trypanosoma cruzi trans-sialidase. A tool for the synthesis of sialylated oligosaccharides [J] . Agusti Rosalia, Gallo-Rodriguez Carola, de Lederkremer Rosa M. Carbohydrate research . 2019,第期

机译：锥虫瘤Cruzi Trans-Sialidase。用于合成唾液酸化寡糖的工具
3. Enzyme catalysed production of sialylated human milk oligosaccharides and galactooligosaccharides by Trypanosoma cruzi trans-sialidase [J] . Jesper Holck, Dorte M. Larsen, Malwina Michalak, New biotechnology . 2014,第2期

机译：克鲁氏锥虫反唾液酸酶酶催化生产唾液酸化的人乳低聚糖和低聚半乳糖
4. Synthesis of Oligosaccharide derived from Pathogenic E.coli UsingBoronic-Acid-Catalyzed Regio-and Stereoselective β-Rhamnosylation [C] . Nobuya Nishi, Katsunori Seki, Daisuke Takahashi 日本化学会春季年会 . 2020

机译：衍生自致胆酸催化的Regio-and StereoSelectiveβ-rhamnosation的源于致病大肠杆菌的寡糖的合成
5. Design, synthesis, and biological evaluation of molecules of medicinal interest: Inhibitors of mammalian and Trypanosoma cruzi protein farnesyltransferase and Trypanosoma cruzi lanosterol-14-alpha-demethylase. [D] . Lockman, Jeffrey William. 2003

机译：设计，合成和具有药用价值的分子的生物学评估：哺乳动物和克鲁斯锥虫蛋白法尼基转移酶和克鲁斯锥虫羊毛甾醇14-α-脱甲基酶的抑制剂。
6. Synthesis and Characterization of Sialylated Lactose-and Lactulose-Derived Oligosaccharides by Trypanosoma cruzi Trans-sialidase [O] . Hien T.T. Pham, Geert A. ten Kate, Lubbert Dijkhuizen, -1

机译：唾液酸化乳糖的合成与表征克氏锥虫转唾液酸酶产生的乳糖和乳果糖寡糖
7. Enzyme catalysed production of sialylated human milk oligosaccharides and galactooligosaccharides by Trypanosoma cruzi trans-sialidase [O] . Holck Jesper, Larsen Dorte M., Michalak Malwina, 2014

机译：克鲁氏锥虫反唾液酸酶的酶催化生产唾液酸化的人乳低聚糖和低聚半乳糖

Transsialidase from Trypanosoma cruzi for Regio-and Stereoselective Synthesis of N-Acyl-Modified Sialylated Oligosaccharides and Measurement of Transfer Rates

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