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首页> 外文期刊>Plastic and reconstructive surgery >Characterization of nonthermal focused ultrasound for noninvasive selective fat cell disruption (lysis): technical and preclinical assessment.
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Characterization of nonthermal focused ultrasound for noninvasive selective fat cell disruption (lysis): technical and preclinical assessment.

机译：非热聚焦超声用于非侵入性选择性脂肪细胞破坏（裂解）的表征：技术和临床前评估。

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BACKGROUND: There has been a lack of published bench and preclinical data supporting the safety and effectiveness of a noninvasive, nonthermal, focused ultrasound technology for body contouring. METHODS: A series of experiments were conducted with a transcutaneous focused ultrasound device (UltraShape Contour I; UltraShape Inc., Yoqneam, Israel): (1) three-dimensional acoustic field distribution was measured by hydrophone in a water bath; (2) the real-time two-dimensional acoustic field was assessed using optical visualization by a Schlieren system; (3) three-dimensional and Schlieren results were compared in tissue-mimicking gel phantoms and in frozen specimens of porcine subcutaneous fat; and (4) a porcine in vivo preclinical model was used to test safety, selectivity, and efficacy by histological staining of excised skin and subcutaneous fat specimens. RESULTS: Real-time imaging of acoustic field distribution obtained by the Schlieren system, as well as real-time ultrasound visualization, produced stable cavitation both in water and in the gel phantoms. The area where the effect was visible corresponded to the focal area of energy delivered by the system transducer, as measured by the hydrophone. Histologically stained specimens of skin and subcutaneous fat that were excised from porcine studies (n = 14) following treatments (n = 31) demonstrated fat cell lysis and no observable cellular destruction of adjacent blood vessels, nerves, and connective tissue. No epidermal or dermal changes were observed clinically or histologically. CONCLUSIONS: The delivery of noninvasive focused ultrasonic energy has been validated and supported by the basic and preclinical data presented. Future studies will investigate various treatment regimens for improved body-contouring results.
机译：背景：缺乏公开的试验台和临床前数据支持无创，非热，聚焦超声技术进行人体轮廓的安全性和有效性。方法：使用经皮聚焦超声设备（UltraShape Contour I; UltraShape Inc.，以色列约克尼姆）进行了一系列实验：（1）在水浴中通过水听器测量三维声场分布; （2）通过Schlieren系统使用光学可视化评估实时二维声场; （3）在组织模拟凝胶体模和冷冻的猪皮下脂肪样本中比较了三维和Schlieren结果; （4）使用猪体内临床前模型通过对切除的皮肤和皮下脂肪样本进行组织学染色来测试安全性，选择性和功效。结果：通过Schlieren系统获得的声场分布的实时成像以及实时超声可视化，在水和凝胶体模中均产生了稳定的空化现象。可见效果的区域对应于由水听器测量的系统换能器传递的能量聚焦区域。在处理（n = 31）后，从猪研究（n = 14）中切除的皮肤和皮下脂肪的组织学染色标本显示脂肪细胞溶解，并且未观察到相邻血管，神经和结缔组织的细胞破坏。临床或组织学上均未观察到表皮或真皮变化。结论：无创聚焦超声能量的传递已得到基础和临床前数据的验证和支持。未来的研究将研究各种治疗方案，以改善身体轮廓。

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