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首页> 外文期刊>BJU international >Technical characterization of an ultrasound source for noninvasive thermoablation by high-intensity focused ultrasound.
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Technical characterization of an ultrasound source for noninvasive thermoablation by high-intensity focused ultrasound.

机译：高强度聚焦超声用于无创热消融的超声源的技术特性。

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Objective To develop a generator for high-intensity focused ultrasound (HIFU, a method of delivering ultrasonic energy with resultant heat and tissue destruction to a tight focus at a selected depth within the body), designed for extracorporeal coupling to allow various parenchymal organs to be treated. Material and methods The ultrasound generated by a cylindrical piezo-ceramic element is focused at a depth of 10 cm using a parabolic reflector with a diameter of 10 cm. A diagnostic B-mode ultrasonographic transducer is integrated into the source to allow the focus to be located in the target area. The field distribution of the sound pressure was measured in degassed water using a needle hydrophone. An ultrasound-force balance was used to determine the acoustic power. These measurements allowed the spatially averaged sound intensity to be calculated. The morphology and extent of tissue necrosis induced by HIFU was examined on an ex-vivo kidney model. Results The two-dimensional field distribution resulted in an approximately ellipsoidal focus of 32x4 mm (- 6 dB). The spatially maximum averaged sound intensity was 8591 W/cm2 at an electrical power of 400 W. The lesion caused to the ex-vivo kidney at this maximum generator power with a pulse duration of 2 s was a clearly delineated ellipsoidal coagulation necrosis up to 8.8x2.3 mm (lengthxwidth) and with central liquefied necrosis of 7.9x1.9 mm. Conclusion This newly developed ultrasound generator with a focal length of 10 cm can induce clear necrosis in parenchymal tissue. Because of its specific configuration and the available power range of the ultrasound generator, there is potential for therapeutic noninvasive ablation of tissue deep within a patient's body.
机译：目的开发一种用于高强度聚焦超声的发生器（HIFU，一种将超声能量以及热和组织破坏产生的超声能量传递到体内选定深度的紧密焦点的方法），其设计用于体外耦合以允许各种实质器官治疗。材料和方法使用直径为10 cm的抛物面反射器将圆柱形压电陶瓷元件产生的超声波聚焦在10 cm的深度。诊断B型超声检查换能器集成到源中，以使焦点位于目标区域。使用针式水听器在脱气水中测量声压的场分布。超声力平衡被用来确定声功率。这些测量允许计算空间平均声音强度。在离体肾脏模型上检查了HIFU诱导的组织坏死的形态和程度。结果二维场分布导致大约32x4 mm（-6 dB）的椭圆形焦点。在400 W的电功率下，空间最大平均声音强度为8591 W / cm2。在此最大发生器功率下，以2 s的脉冲持续时间对离体肾脏造成的病变是一个清晰描绘的椭圆形凝固坏死，最高为8.8。 x2.3 mm（长x宽），中央液化坏死为7.9x1.9 mm。结论这种新开发的焦距为10 cm的超声发生器可以在实质组织中引起明显的坏死。由于其特定的配置和超声发生器的可用功率范围，有可能对患者体内深处的组织进行非侵入性的治疗性消融。

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