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首页> 外文期刊>Chemistry: A European journal >Non-covalent polyvalent ligands by self-assembly of small glycodendrimers: A novel concept for the inhibition of polyvalent carbohydrate-protein interactions in vitro and in vivo
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Non-covalent polyvalent ligands by self-assembly of small glycodendrimers: A novel concept for the inhibition of polyvalent carbohydrate-protein interactions in vitro and in vivo

机译：通过小的糖类树状聚合物的自组装的非共价多价配体：体外和体内抑制多价碳水化合物-蛋白质相互作用的新概念。

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摘要

Polyvalent carbohydrate-protein interactions occur frequently in biology, particularly in recognition events on cellular membranes. Collectively, they can be much stronger than corresponding monovalent interactions, rendering it difficult to control them with individual small molecules. Artificial macromolecules have been used as polyvalent ligands to inhibit polyvalent processes; however, both reproducible synthesis and appropriate characterization of such complex entities is demanding. Herein, we present an alternative concept avoiding conventional macromolecules. Small glycodendrimers which fulfill single molecule entity criteria self-assemble to form non-covalent nanoparticles. These particles-not the individual molecules-function as polyvalent ligands, efficiently inhibiting polyvalent processes both in vitro and in vivo. The synthesis and characterization of these glycodendrimers is described in detail. Furthermore, we report on the characterization of the non-covalent nanoparticles formed and on their biological evaluation.
机译：多价碳水化合物与蛋白质的相互作用在生物学中经常发生，特别是在细胞膜上的识别事件中。总的来说，它们可能比相应的单价相互作用强得多，这使得很难用单个小分子控制它们。人造大分子已被用作多价配体，以抑制多价过程。然而，对此类复杂实体的可复制合成和适当表征都要求。在本文中，我们提出了避免常规大分子的替代概念。满足单分子实体标准的小型糖类树状聚合物自组装形成非共价纳米颗粒。这些颗粒而不是单个分子起着多价配体的作用，在体外和体内均有效地抑制了多价过程。这些糖类树状大分子的合成和表征详细描述。此外，我们报告了形成的非共价纳米粒子的表征及其生物学评估。

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