• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Chemistry: A European journal >Non-Covalent Polyvalent Ligands by Self-Assembly of Small Glycodendrimers: A Novel Concept for the Inhibition of Polyvalent Carbohydrate-Protein Interactions In Vitro and In Vivo
【24h】

Non-Covalent Polyvalent Ligands by Self-Assembly of Small Glycodendrimers: A Novel Concept for the Inhibition of Polyvalent Carbohydrate-Protein Interactions In Vitro and In Vivo

机译：小糖蛋白自组装体的非共价多价配体：抑制体内和体外多价碳水化合物与蛋白质相互作用的新概念。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Polyvalent carbohydrate-protein interactions occur frequently in biology,particularly in recognition events on cellular membranes.Collectively,they can be much stronger than corresponding monovalent interactions,rendering it difficult to control them with individual small molecules.Artificial macromolecules have been used as polyvalent ligands to inhibit polyvalent processes;however,both reproducible synthesis and appropriate characterization of such complex entities is demanding.Herein,we present an alternative concept avoiding conventional macromolecules.Small glycodendrim-ers which fulfill single molecule entity criteria self-assemble to form non-co-valent nanoparticles.These particles- not the individual molecules-function as polyvalent ligands,efficiently inhibiting polyvalent processes both in vitro and in vivo.The synthesis and characterization of these glycodendrimers is described in detail.Furthermore,we report on the characterization of the non-covalent nanoparticles formed and on their biological evaluation.
机译：多价碳水化合物与蛋白质的相互作用在生物学中经常发生，特别是在细胞膜上的识别事件中。集体地，它们比相应的单价相互作用要强得多，这使得很难用单个小分子来控制它们。人工大分子已被用作多价配体。抑制多价过程;但是，对此类复杂实体的可重现合成和适当表征都要求。在此，我们提出了避免常规大分子的另一种概念。满足单分子实体标准的小糖类分子自组装形成非共价这些颗粒而不是单个分子起着多价配体的作用，有效地抑制了体内和体外的多价过程。详细描述了这些糖类树状大分子的合成和表征。此外，我们报道了非共价的表征纳米颗粒形成并对其进行生物学评估。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号