Structure and total synthesis of aspernigerin: A novel cytotoxic endophyte metabolite

Shen L; Ye YH; Wang XT; Zhu HL; Xu C; Song YC; Li H; Tan RX

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Structure and total synthesis of aspernigerin: A novel cytotoxic endophyte metabolite

机译：曲霉菌素的结构和全合成：一种新型的细胞毒性内生代谢物

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Aspernigerin (1), a novel cytotoxic alkaloid consisting of an unprecedented structural framework has been isolated from the extract of a culture of Aspergillus niger IFB-E003, an endophyte in Cyndon dactylon. Its structure was elucidated on the basis of comprehensive NMR spectral analysis and confirmed by single-crystal X-ray analysis. Aspernigerin (1) has been shown to be cytotoxic to the tumor cell lines nasopharynyeal epidermoid KB, cervical carcinoma Hela, and colorectal carcinoma SW1116 with corresponding IC50 values of 22, 46, and 35 mu m, respectively. A feasible total synthetic route for aspernigerin (1) has been established for further pharmacological research.

机译：从黑曲霉IFD-E003的培养物提取物中分离出了曲霉菌素（1），它是一种由前所未见的结构框架组成的新型细胞毒性生物碱。在全面的NMR光谱分析的基础上阐明了其结构，并通过单晶X射线分析对其进行了确认。已显示曲霉菌素（1）对鼻咽上皮表皮样KB，宫颈癌Hela和结直肠癌SW1116等肿瘤细胞系具有细胞毒性，其IC50值分别为22、46和35μm。已经建立了可行的曲霉菌素（1）的总合成途径，以用于进一步的药理研究。

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《Chemistry: A European journal》 |2006年第16期|共4页
作者
Shen L; Ye YH; Wang XT; Zhu HL; Xu C; Song YC; Li H; Tan RX;
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正文语种 eng
中图分类化学;
关键词
aspernigerin; cytotoxic; endophyte; structure elucidation; total synthesis; CONFIGURATION; AMIDES; ACID;

机译：曲霉菌素;细胞毒性;内生菌;结构解析;全合成;构型;酰胺;酸;

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1. Structure and total synthesis of aspernigerin: A novel cytotoxic endophyte metabolite [J] . Shen L, Ye YH, Wang XT, Chemistry: A European journal . 2006,第16期

机译：曲霉菌素的结构和全合成：一种新型的细胞毒性内生代谢物
2. Highly Convergent Total Synthesis and Assignment of Absolute Configuration of Majusculamide D, a Potent and Selective Cytotoxic Metabolite from Moorea sp. (vol 21, pg 793, 2019) [J] . Caro-Diaz Eduardo J. E., Valeriote Frederick A., Gerwick William H. Organic letters . 2020,第15期

机译：高度收敛总合成和散氨酰胺D的绝对配置分配，来自Moorea SP的有效和选择性细胞毒性代谢物。（Vol 21，PG 793,2019）
3. Highly Convergent Total Synthesis and Assignment of Absolute Configuration of Majusculamide D, a Potent and Selective Cytotoxic Metabolite from Moorea sp [J] . Caro-Diaz Eduardo J. E., Valeriote Frederick A., Gerwick William H. Organic letters . 2019,第3期

机译：高收敛的总合成和散美构型散霉属D，富有效果和选择性细胞毒性代谢物的总结合成和分配
4. Progress toward the total synthesis of a cytotoxic norditerpene from Cephalotaxus sp. : the hainanolide (or harringtonolide)(Abstracts) [C] . Laurent Evanno, Bernard Bodo, Bastien Nay European Symposium on Organic Chemistry . 2007

机译：从头孢菌SP中朝着细胞毒性偏移的总合成的进展。：HainaNolide（或Harringtonolide）（摘要）
5. Total synthesis of microtubule stabilizing agent laulimalide and total syntheses of proposed structure of cytotoxic macrolide iriomoteolide-1a and -1b. [D] . Yuan, Hao. 2011

机译：微管稳定剂laulimalide的全合成和细胞毒性大环内酯iriomoteolide-1a和-1b拟议结构的总合成。
6. Cytotoxic activity of crude extracts from Datura stramonium’s fungal endophytes against A549 lung carcinoma and UMG87 glioblastoma cell lines and LC-QTOF-MS/MS based metabolite profiling [O] . Kudzanai Ian Tapfuma, Nkemdinma Uche-Okereafor, Tendani Edith Sebola, 2019

机译：曼陀罗属真菌内生菌粗提物的粗提物对A549肺癌和UMG87胶质母细胞瘤细胞系以及基于LC-QTOF-MS / MS的代谢物谱分析的细胞毒活性
7. Correction to “Highly Convergent Total Synthesis and Assignment of Absolute Configuration of Majusculamide D, a Potent and Selective Cytotoxic Metabolite from Moorea sp.” [O] . Eduardo J. E. Caro-Diaz, Frederick A. Valeriote, William H. Gerwick 2020

机译：校正“高度收敛总合成和散氨酸绝对配置的分配，来自Moorea SP的强效和选择性细胞毒性代谢物”。

Structure and total synthesis of aspernigerin: A novel cytotoxic endophyte metabolite

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