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首页> 外文期刊>The American Journal of the Medical Sciences >The health education for lupus study: A randomized controlled cognitive-behavioral intervention targeting psychosocial adjustment and quality of life in adolescent females with systemic lupus erythematosus
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The health education for lupus study: A randomized controlled cognitive-behavioral intervention targeting psychosocial adjustment and quality of life in adolescent females with systemic lupus erythematosus

机译：狼疮研究的健康教育：针对系统性红斑狼疮青春期女性的心理社会适应和生活质量的随机对照认知行为干预

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Introduction: To examine in a randomize controlled feasibility clinical trial the efficacy of a cognitive-behavioral intervention designed to manage pain, enhance disease adjustment and adaptation and improve quality of life among female adolescents with systemic lupus erythematosus. Methods: Female adolescents (n = 53) ranging in age from 12 to 18 years were randomly assigned to 1 of 3 groups including a cognitive-behavioral intervention, an education-only arm and a no-contact control group. Participants were assessed at baseline, postintervention and at 3- and 6-month intervals after completion of the intervention. Results: No significant differences were revealed among the 3 treatment arms for any of the dependent measures at any of the assessment points. For the mediator variables, a posthoc secondary analysis did reveal increases in coping skills from baseline to postintervention among the participants in the cognitive-behavioral intervention group compared with both the no-contact control group and the education-only group. Conclusion: Although no differences were detected in the primary outcome, a possible effect on coping of female adolescents with systemic lupus erythematosus was detected in this feasibility study. Whether the impact of training in the area of coping was of sufficient magnitude to generalize to other areas of functioning, such as adjustment and adaptation, is unclear. Future phase III randomized trials will be needed to assess additional coping models and to evaluate the dose of training and its influence on pain management, adjustment and health-related quality of life.
机译：简介：在一项随机对照的可行性临床试验中，研究旨在改善系统性红斑狼疮女性青少年的疼痛，增强疾病适应和适应能力以及改善生活质量的认知行为干预措施的有效性。方法：将年龄在12至18岁之间的女性青少年（n = 53）随机分配到3组中的1组，包括认知行为干预，仅接受教育的手臂和无接触对照组。在完成干预后，在基线，干预后以及3个月和6个月的时间间隔对参与者进行评估。结果：在三个评估组中，在任何评估点的任何依赖措施中均未发现显着差异。对于中介变量，事后的二次分析确实显示了与非接触对照组和纯教育组相比，认知行为干预组参与者从基线到干预后的应对技能有所提高。结论：尽管在主要结局方面未发现差异，但在该可行性研究中发现了对女性青少年应对系统性红斑狼疮的可能影响。尚不清楚培训在应对领域的影响是否足以概括到其他职能领域，例如调整和适应。未来将需要进行第三阶段的随机试验，以评估其他应对模型，并评估培训的剂量及其对疼痛管理，适应和健康相关生活质量的影响。

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