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首页> 外文期刊>The American Journal of Surgery >Intrahepatic cholangiocarcinoma: analysis of 44 consecutive resected cases including 5 cases with repeat resections.
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Intrahepatic cholangiocarcinoma: analysis of 44 consecutive resected cases including 5 cases with repeat resections.

机译：肝内胆管癌：分析44例连续切除的病例，其中5例重复切除。

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摘要

BACKGROUND: Prognosis after resection for intrahepatic cholangiocarcinoma (ICC) remains unsatisfactory. There remains no effective therapy after recurrent ICC. OBJECTIVE: The current study sought to evaluate risk factors associated with recurrent ICC and possible therapies after resection. METHOD: A review of data from patients who underwent potentially curative resection for ICC was performed. RESULTS: A total of 44 potentially curative resections were performed from 1995 to 2008. Mortality was 0% and morbidity was 35%. The 5-year overall and recurrence-free survival rates were 43% and 39%, respectively. Multivariate analysis identified the presence of multiple nodules and poor histologic grade as independent negative prognostic factors for overall and recurrent-free survival. Postoperative recurrence occurred in 25 patients (57%). Solitary recurrence occurred in 5 patients (liver, n = 4; lung, n = 1), all of who had undergone surgical resection. Three of the 5 patients survived for more than 5 years after 2 resections. CONCLUSION: Prognosis after curative resection of solitary ICC appears favorable. In selected patients with sequential single hepatic or pulmonary recurrence, repeat resection may prolong survival.
机译：背景：肝内胆管癌（ICC）切除后的预后仍然不理想。 ICC复发后仍没有有效的治疗方法。目的：本研究旨在评估与ICC复发相关的危险因素以及切除后可能的治疗方法。方法：对接受ICC可能根治性切除术的患者的数据进行回顾。结果：从1995年至2008年，共进行了44例可能治愈的切除术。死亡率为0％，发病率为35％。 5年总生存率和无复发生存率分别为43％和39％。多变量分析确定存在多个结节和不良的组织学分级是整体和无复发生存的独立阴性预后因素。 25例患者（57％）发生术后复发。孤立性复发发生在所有5例患者中（肝，n = 4;肺，n = 1），所有患者均接受了手术切除。 5例患者中有3例在2次切除后存活超过5年。结论：孤立性ICC根治性切除术后预后良好。在选择的具有顺序性单肝或肺复发的患者中，重复切除可延长生存期。

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