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首页> 外文期刊>The American Journal of Surgery >Predictive utility of cyclo-oxygenase-2 expression by colon and rectal cancer
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Predictive utility of cyclo-oxygenase-2 expression by colon and rectal cancer

机译：结肠和直肠癌中环氧合酶2表达的预测效用

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Background: Cyclo-oxygenase-2 (COX-2), an inducible enzyme expressed in areas of inflammation, is a target of interest for colorectal cancer therapy. Currently, the predictive significance of COX-2 in colorectal cancer remains unclear. Methods: Tissue microarrays were constructed using 118 colon cancer and 85 rectal cancer specimens; 44 synchronous metastatic colon cancer and 22 rectal cancer lymph nodes were also evaluated. COX-2 expression was assessed by immunohistochemistry. Univariate analysis was used to determine the predictive significance of clinicopathologic variables. Overall survival, disease-specific survival, and disease-free survival were the main outcomes examined. Results: COX-2 was found to be expressed in 93% of colon cancers and 87% of rectal cancers. Decreased COX-2 expression was related to decreased disease-specific survival (P =.016) and decreased disease-free survival (P =.019) in the rectal cancer cohort but not in the colon cancer cohort. Conclusions: COX-2 expression has predictive utility for management of rectal but not colon cancer.
机译：背景：环氧合酶2（COX-2）是在炎症区域表达的一种可诱导酶，是结直肠癌治疗的重要靶标。目前，COX-2在结直肠癌中的预测意义尚不清楚。方法：利用118例结肠癌和85例直肠癌标本构建组织芯片。还评估了44例同步转移性结肠癌和22例直肠癌淋巴结。通过免疫组织化学评估COX-2表达。单因素分析用于确定临床病理变量的预测意义。总体生存率，疾病特异性生存率和无疾病生存率是研究的主要结果。结果：发现COX-2在93％的结肠癌和87％的直肠癌中表达。 COX-2表达降低与直肠癌队列中疾病特异性生存率降低（P = .016）和无病生存率降低（P = .019）有关，而与结肠癌队列无关。结论：COX-2表达对直肠癌的治疗具有预测作用，但对结肠癌的治疗没有预测作用。

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