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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Asymptomatic Plasmodium infection and cognition among primary schoolchildren in a high malaria transmission setting in Uganda
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Asymptomatic Plasmodium infection and cognition among primary schoolchildren in a high malaria transmission setting in Uganda

机译：乌干达疟疾高发地区小学生无症状疟原虫感染和认知

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摘要

Asymptomatic parasitemia is common among schoolchildren living in areas of high malaria transmission, yet little is known about its effect on cognitive function in these settings. To investigate associations between asymptomatic parasitemia, anemia, and cognition among primary schoolchildren living in a high malaria transmission setting, we studied 740 children enrolled in a clinical trial in Tororo, Uganda. Parasitemia, measured by thick blood smears, was present in 30% of the children. Infected children had lower test scores for abstract reasoning (adjusted mean difference [AMD] -0.6, 95% confidence interval [CI] -1.01 to -0.21) and sustained attention (AMD -1.6 95% CI -2.40 to -0.81) compared with uninfected children. There was also evidence for a dose-response relationship between parasite density and scores for sustained attention. No associations were observed between anemia and either test of cognition. Schoolchildren in high transmission settings may experience cognitive benefits, from interventions aimed at reducing the prevalence of asymptomatic parasitemia.
机译：在疟疾高发地区的学童中，无症状寄生虫病很常见，但在这些情况下其对认知功能的影响知之甚少。为了研究无症状寄生虫性贫血，贫血和生活在高疟疾传播环境中的小学生之间的认知之间的关联，我们研究了740名在乌干达托罗罗参加临床试验的儿童。通过浓血涂片测量的寄生虫血症存在于30％的儿童中。与抽象推理相比，受感染儿童的抽象推理测验分数（调整后的平均差异[AMD] -0.6、95％置信区间[CI] -1.01至-0.21）和持续关注（AMD -1.6 95％CI -2.40至-0.81）较低。未感染的孩子。也有证据表明寄生虫密度和持续关注分数之间存在剂量反应关系。贫血和任何一项认知测试之间均未发现关联。旨在减少无症状寄生虫病流行的干预措施可使处于高传播环境的学童获得认知益处。

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