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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Profiling of human acquired immunity against the salivary proteins of phlebotomus papatasi reveals clusters of differential immunoreactivity
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Profiling of human acquired immunity against the salivary proteins of phlebotomus papatasi reveals clusters of differential immunoreactivity

机译：人类获得的针对木麻雀唾液蛋白的免疫性分析揭示了不同的免疫反应性簇

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摘要

Phlebotomus papatasi sand flies are among the primary vectors of Leishmania major parasites from Morocco to the Indian subcontinent and from southern Europe to central and eastern Africa. Antibody-based immunity to sand fly salivary gland proteins in human populations remains a complex contextual problem that is not yet fully understood. We profiled the immunoreactivities of plasma antibodies to sand fly salivary gland sonicates (SGSs) from 229 human blood donors residing in different regions of sand fly endemicity throughout Jordan and Egypt as well as 69 US military personnel, who were differentially exposed to P. papatasi bites and L. major infections in Iraq. Compared with plasma from control region donors, antibodies were significantly immunoreactive to five salivary proteins (12, 26, 30, 38, and 44 kDa) among Jordanian and Egyptian donors, with immunoglobulin G4 being the dominant anti-SGS isotype. US personnel were significantly immunoreactive to only two salivary proteins (38 and 14 kDa). Using k-means clustering, donors were segregated into four clusters distinguished by unique immunoreactivity profiles to varying combinations of the significantly immunogenic salivary proteins. SGS-induced cellular proliferation was diminished among donors residing in sand fly-endemic regions. These data provide a clearer picture of human immune responses to sand fly vector salivary constituents.
机译：从摩洛哥到印度次大陆以及从南欧到中部和东部非洲，利什曼原虫的主要寄生虫是枯萎侧柏蝇。对人群中的沙蝇唾液腺蛋白的基于抗体的免疫仍然是一个复杂的背景问题，目前尚未完全了解。我们分析了约旦和埃及各地229名居住在沙蝇流行地区不同地区的人类献血者以及69名美国军人的血浆抗体对沙蝇唾液腺超声（SGS）的免疫反应性，这些人有不同程度地暴露于P. papatasi叮咬和L.在伊拉克的重大感染。与来自对照区供体的血浆相比，抗体对约旦和埃及供体中的五种唾液蛋白（12、26、30、38和44 kDa）具有显着的免疫反应性，其中免疫球蛋白G4是主要的抗SGS亚型。美国人员仅对两种唾液蛋白（38和14 kDa）具有明显的免疫反应性。使用k-均值聚类，将供体分为四个簇，这些簇的独特免疫反应谱与显着免疫原性唾液蛋白的不同组合区分开。居住在沙蝇流行地区的供体中，SGS诱导的细胞增殖减少。这些数据提供了人类对沙蝇媒介唾液成分的免疫反应的更清晰图片。

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