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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >High Prevalence of Antimicrobial Resistance Among Common Bacterial Isolates in a Tertiary Healthcare Facility in Rwanda
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High Prevalence of Antimicrobial Resistance Among Common Bacterial Isolates in a Tertiary Healthcare Facility in Rwanda

机译：卢旺达第三级医疗机构常见细菌分离株中抗菌素耐药性高发

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摘要

Antimicrobial resistance (AMR) is a serious public health threat in both developed and developing countries. Many developing countries, including Rwanda, lack adequate surveillance systems, and therefore, the prevalence of AMR is not well-known. We conducted a prospective observational study to assess the prevalence of AMR among common bacterial isolates from clinical specimens obtained from patients on the medical wards of Kigali University Teaching Hospital (KUTH). We evaluated the antibiotic sensitivity patterns of bacterial pathogens cultured from urine, blood, sputum, and wound swab specimens obtained over a 6-month period (July 1 to December 30, 2013). There were 154 positive cultures from specimens obtained from 141 unique patients over the study period. Urine, blood, wound swab, and sputum cultures comprised 55.2%, 25.3%, 16.2%, and 3.3% of the total specimens evaluated; 31.4% and 58.7% of Escherichia coli and Klebsiella isolates, respectively, were resistant to at least one of the third generation cephalosporins. Eight percent of E. coli isolates were resistant to imipenem; 82% and 6% of Staphylococcus aureus strains were oxacillin- and vancomycin-resistant respectively. Antimicrobial resistance rates are high in Rwanda and pose a serious therapeutic challenge to the management of common infections.
机译：在发达国家和发展中国家，抗菌素耐药性（AMR）都是严重的公共卫生威胁。包括卢旺达在内的许多发展中国家缺乏适当的监视系统，因此，抗菌素耐药性的流行并不为人所知。我们进行了一项前瞻性观察性研究，以评估从基加利大学教学医院（KUTH）病房的患者获得的临床标本中常见细菌分离株中AMR的患病率。我们评估了从六个月（2013年7月1日至12月30日）获得的尿液，血液，痰液和伤口拭子样本培养的细菌性病原体的抗生素敏感性模式。在研究期间，从141位独特患者的标本中获得了154种阳性培养物。尿液，血液，伤口拭子和痰培养物分别占所评估标本的55.2％，25.3％，16.2％和3.3％。大肠埃希菌和克雷伯菌的分离株分别有31.4％和58.7％对至少一种第三代头孢菌素具有抗性。百分之八的大肠杆菌分离株对亚胺培南有抗药性。金黄色葡萄球菌菌株分别有82％和6％对奥沙西林和万古霉素耐药。卢旺达的抗菌素耐药率很高，对常见感染的管理提出了严峻的治疗挑战。

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