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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Differentiation between non-virulent and virulent Burkholderia pseudomallei with monoclonal antibodies to the Ara+ or Ara- biotypes.
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Differentiation between non-virulent and virulent Burkholderia pseudomallei with monoclonal antibodies to the Ara+ or Ara- biotypes.

机译：用针对Ara +或Ara-生物型的单克隆抗体区分非毒力和强毒性伯克霍尔德氏菌。

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摘要

Burkholderia pseudomallei is the causative agent of melioidosis, a fatal tropical infectious disease endemic in Southeast Asia. Environmental isolates of B. pseudomallei have two distinctive biotypes. Some soil isolates are arabinose-assimilators (Ara+ biotype) and are non-virulent in experimental animals. The others cannot assimilate arabinose (Ara- biotype) and are virulent in experimental animals. The Ara- biotype is found in almost all B. pseudomallei clinical isolates. In the present study, a panel of eight monoclonal antibodies that agglutinate the bacteria were produced and tested. The first group, Bps-D2, -D3, -D5, -L1, and -L2 agglutinated 100% of Ara+ clinical and soil isolates of B. pseudomallei. Another group Bps-A1, -A2, and -D1 agglutinated 92.9% and 90.9% of Ara- clinical and soil isolates, respectively. This panel of monoclonal antibodies may be useful for rapid differentiation between non-virulent Ara+ and virulent Ara- B. pseudomallei.
机译：假伯克霍尔德氏菌是类鼻疽病的病原体，后者是东南亚地区一种致命的热带传染病。假苹果芽孢杆菌的环境分离株具有两种独特的生物型。一些土壤分离物是阿拉伯糖同化剂（Ara +生物型），在实验动物中没有毒力。其他的则不能吸收阿拉伯糖（阿拉伯生物型），并且在实验动物中具有毒性。几乎在所有假疟原虫临床分离物中都发现了Ara生物型。在本研究中，产生并测试了八种可凝集细菌的单克隆抗体。第一组是Bps-D2，-D3，-D5，-L1和-L2，它们会凝集100％的拟南芥Bra临床和土壤分离物。另一组Bps-A1，-A2和-D1分别凝集了Ara-临床分离株和土壤分离株的92.9％和90.9％。这组单克隆抗体可用于快速区分非毒性的Ara +和有毒的Ara- B. pseudomallei。

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