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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Impaired microcirculation and tissue oxygenation in human cerebral malaria: a single photon emission computed tomography and near-infrared spectroscopy study.
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Impaired microcirculation and tissue oxygenation in human cerebral malaria: a single photon emission computed tomography and near-infrared spectroscopy study.

机译：人脑疟疾中的微循环和组织氧合受损：单光子发射计算机断层扫描和近红外光谱研究。

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摘要

Serial single photon emission computed tomography (SPECT), near-infrared spectroscopy (NIRS), and transcranial doppler (TCD) sonography examinations were performed to investigate changes of cerebral perfusion and tissue oxygenation in a patient with complicated cerebral malaria that have been acquired in Nigeria. On admission to the Neurologic Intensive Care Unit in Innsbruck, Austria, SPECT and NIRS revealed focal right hemispheric hypoperfusion and decreased oxygen saturation, respectively, correlating exactly to the patient's right hemispheric localizing signs. In contrast, TCD examinations of the basal cerebral vessels revealed normal flow patterns. The patient showed an initial Plasmodium falciparum parasitemia rate of 30% and was cured by intravenous quinine and oral mefloquine therapy. He was discharged without neurologic symptoms. Follow-up SPECT and NIRS examinations revealed regular cerebral perfusion and oxygenation patterns in both cortical hemispheres. In summary, the presented findings provide first evidence that noninvasive SPECT and NIRS may be important diagnostic tools in the evaluation of impaired cerebral microcirculation in patients with P. falciparum malaria.
机译：进行了串行单光子发射计算机断层扫描（SPECT），近红外光谱（NIRS）和经颅多普勒（TCD）超声检查，以调查在尼日利亚获得的患有复杂性脑疟疾的患者的脑灌注和组织氧合的变化。 。进入奥地利因斯布鲁克的神经重症监护病房后，SPECT和NIRS分别显示了右半球局部灌注不足和血氧饱和度降低，这与患者的右半球局部定位征兆完全相关。相反，对基底脑血管的TCD检查显示血流正常。该患者最初的恶性疟原虫寄生率为30％，并通过静脉注射奎宁和口服甲氟喹治疗而治愈。他出院时无神经系统症状。后续的SPECT和NIRS检查显示两个大脑皮层半球都有规律的脑灌注和氧合模式。总之，提出的发现提供了第一个证据，即无创SPECT和NIRS可能是评估恶性疟原虫患者脑微循环受损的重要诊断工具。

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