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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >A large outbreak of histoplasmosis among American travelers associated with a hotel in Acapulco, Mexico, spring 2001.
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A large outbreak of histoplasmosis among American travelers associated with a hotel in Acapulco, Mexico, spring 2001.

机译：2001年春季，与墨西哥阿卡普尔科一家酒店有关的美国旅行者中发生了大规模的组织胞浆菌病。

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During spring 2001, college students from Pennsylvania reported an acute febrile respiratory illness after returning from spring break vacation in Acapulco, Mexico. Acute pulmonary histoplasmosis was presumptively diagnosed and the cluster of illness was reported to the Centers of Disease Control and Prevention. A large investigation then ensued, which included finding student-travelers for interviews and requesting sera for histoplasmosis testing. We defined a clinical case by fever and at least one of the following: cough, shortness of breath, chest pain, or headache, in an Acapulco traveler during March-May 2001. A laboratory-confirmed case had positive serology. An initial study determined that the likely site of histoplasmosis exposure was Hotel H; we therefore performed a large cohort study among travelers who stayed at Hotel H. Of 757 contacted, 262 (36%) met the clinical case definition. Of 273 serum specimens tested, 148 (54%) were positive. Frequent use of Hotel H's stairwells, where construction was ongoing, was associated with increased risk of illness (relative risk = 10.5, 95% confidence interval = 3.7-30.5; P < 0.001). This is the first histoplasmosis outbreak associated with a hotel undergoing construction. Hotels in endemic areas should consider construction precaution measures to prevent histoplasmosis among their guests.
机译：2001年春季，宾夕法尼亚州的大学生从春假休假返回墨西哥阿卡普尔科后报告了急性发热性呼吸道疾病。假定诊断为急性肺组织胞浆菌病，并将疾病簇报告给疾病控制与预防中心。随后进行了一次大规模调查，其中包括寻找旅行者来进行访谈，并要求血清进行组织胞浆病检测。我们通过2001年3月至5月间阿卡普尔科旅行者的发烧和以下至少一种症状定义了临床病例：咳嗽，呼吸急促，胸痛或头痛。实验室确诊的病例血清学阳性。初步研究确定，组织胞浆菌病暴露的可能地点是H酒店。因此，我们对住在H酒店的旅行者进行了大规模的队列研究。在与之联系的757名患者中，有262名（36％）符合临床病例定义。在测试的273个血清样本中，有148个（54％）呈阳性。经常使用正在进行建造的H酒店的楼梯间会增加患病的风险（相对危险度= 10.5，95％置信区间= 3.7-30.5; P <0.001）。这是与酒店正在进行建造有关的首次组织胞浆菌病暴发。流行地区的酒店应考虑采取施工预防措施，以防止客人中的组织胞浆菌病。

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