...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Chikungunya Virus Infections among Patients with Dengue-Like Illness at a Tertiary Care Hospital in the Philippines, 2012-2013
【24h】

Chikungunya Virus Infections among Patients with Dengue-Like Illness at a Tertiary Care Hospital in the Philippines, 2012-2013

机译：2012-2013年，菲律宾三级医院的登革热病患者基孔肯雅病毒感染

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chikungunya virus (CHIKV) often co-circulates with dengue virus (DENV). A cross-sectional surveillance study was conducted at a tertiary hospital in Manila, Philippines, to describe the prevalence and characteristics of DENY and CHIKV infections among patients seeking care for dengue-like illness. Acute blood samples from patients 6 months of age clinically diagnosed with dengue from November 2012 to December 2013 underwent reverse transcription polymerase chain reaction (RT-PCR) to detect DENY and CHIKV RNA. A total of 118 patients with clinically diagnosed dengue (age range = 1-89 years, mean = 22 years; male-to-female ratio = 1.51) were tested by DENY RT-PCR; 40 (34%) were DENY PCR-positive (age range = 1-45 years, mean = 17 years). All DENY serotypes were detected: 11 (28%) DENY-1, 6 (15%) DENV-2, 6 (15%) DENV-3, and 17 (42%) DENV-4. Of 112 patients clinically diagnosed with dengue and tested by CHIKV RT-PCR, 11 (10%) were CHIKV PCR-positive (age range = 2-47 years, mean = 20.3 years). No coinfections were detected. Presenting signs/symptoms did not differ between DENY- and CHIKV-positive cases. Sequencing of envelope 1 gene from two CHIKV PCR-positive samples showed Asian genotype. This study highlights the potential for misdiagnosis of medically attended CHIKV infections as DENY infection and the difficulty in clinically differentiating dengue and chikungunya based on presenting signs/symptoms alone. This underscores the necessity for diagnostic laboratory tests to distinguish CHIKV infections in the background of actively co-circulating DENY.
机译：基孔肯雅热病毒（CHIKV）通常与登革热病毒（DENV）共同传播。在菲律宾马尼拉的一家三级医院进行了一项横断面监测研究，以描述寻求登革热样疾病治疗的患者中DENY和CHIKV感染的患病率和特征。从2012年11月至2013年12月在临床上诊断为登革热的6个月大患者的急性血液样本进行了逆转录聚合酶链反应（RT-PCR），以检测DENY和CHIKV RNA。通过DENY RT-PCR检测了118例临床诊断为登革热的患者（年龄范围为1-89岁，平均值= 22岁;男女比例= 1.51）; 40例（34％）是DENY PCR阳性（年龄范围为1-45岁，平均值= 17岁）。检测到所有DENY血清型：11（28％）DENY-1、6（15％）DENV-2、6（15％）DENV-3和17（42％）DENV-4。在临床诊断为登革热并通过CHIKV RT-PCR测试的112例患者中，有11例（10％）是CHIKV PCR阳性的（年龄范围为2-47岁，平均值= 20.3岁）。未检测到合并感染。在DENY和CHIKV阳性病例之间，呈现体征/症状没有差异。来自两个CHIKV PCR阳性样品的envelope 1基因测序显示出亚洲基因型。这项研究强调了将医疗参与的CHIKV感染误诊为DENY感染的可能性，以及仅凭体征/症状在临床上区分登革热和基孔肯雅热的难度。这突显了诊断性实验室测试的必要性，以便在积极协同流通DENY的背景下区分CHIKV感染。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号