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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Comparative pathology, and immunohistology associated with clinical illness after Ehrlichia phagocytophila-group infections.
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Comparative pathology, and immunohistology associated with clinical illness after Ehrlichia phagocytophila-group infections.

机译：埃里希氏噬菌体组感染后与临床疾病相关的比较病理学和免疫组织学。

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摘要

The Ehrlichia phagocytophila-group also includes E. equi and the human granulocytic ehrlichiosis (HGE) agent that are probably a single species. Disease is mild to severe illness in ruminants, horses, and humans, but the comparative pathology and ehrlichial distribution in tissues is poorly described. We compared pathology and ehrlichial distribution in humans with HGE, horses with E. equi infection, and a sheep with E. phagocytophila infection. Frequent findings included splenic lymphoid depletion, small macrophage aggregates and apoptoses in liver, and paracortical hyperplasia in lymph nodes. Bone marrow was normocellular or hypercellular. Only the spleen was frequently infected; other organs with infected cells included lung, liver, heart, and kidney, but lesions were present in lung and liver only. Most infected cells were neutrophils. Ehrlichia phagocytophila-group infections are associated with moderate tissue damage. While the pathogenesis of granulocytic ehrlichiosis is not clear, pathologic studies suggest that the process is initiated by ehrlichia-infected cells but may result from host-mediated injury and immunosuppression.
机译：埃希氏噬菌体组还包括马E. equi和人类粒细胞埃希氏菌病（HGE）药物，它们可能是单一物种。在反刍动物，马和人类中，该疾病为轻度至重度疾病，但是在组织中比较的病理学和埃希氏菌分布很少被描述。我们比较了人类感染HGE，马感染E. equip的马和绵羊感染E. phagocytophila的病理学和埃希氏菌分布。常见的发现包括脾脏淋巴样耗竭，肝脏中小的巨噬细胞聚集和凋亡以及淋巴结中的皮质旁增生。骨髓是正常细胞或高细胞的。只有脾脏经常被感染。细胞感染的其他器官包括肺，肝，心脏和肾脏，但病变仅存在于肺和肝。大多数感染的细胞是嗜中性粒细胞。埃希氏噬菌体组感染与中度组织损伤有关。尽管尚不清楚粒细胞性埃希氏菌病的发病机理，但病理研究表明该过程是由埃希氏菌感染的细胞引发的，但可能是宿主介导的损伤和免疫抑制引起的。

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