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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Hepatitis B infection in rural Vietnam and the implications for a national program of infant immunization.
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Hepatitis B infection in rural Vietnam and the implications for a national program of infant immunization.

机译:越南农村地区的乙型肝炎感染及其对婴儿免疫国家计划的影响。

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摘要

To ascertain hepatitis B virus (HBV) infection rates for Vietnam, we surveyed HBV markers in two districts of Thanh Hoa province. We randomly selected 536 infants (9- < or = 18 months old), 228 children (4 to < or = 6 years old), 219 adolescents (14 to < or = 16 years old), and 596 adults (25 to < or = 40 years old). On questioning, none of those surveyed had received vaccine against HBV. Hepatitis B virus surface antigen (HBsAg) and total HBV core antibody (anti-HBc) were measured in all specimens, and HBV e antigen (HBeAg) in those positive for HBsAg, and HBV surface antibody (anti-HBs) were measured in all others. Current infection (HBsAg+) rates were infants = 12.5%, children = 18.4%, adolescents = 20.5%, and adults = 18.8%. Current or previous infection (HBsAg+, anti-HBc+, or anti-HBs+) increased with age (infants = 19.6%, children = 36.4%, adolescents = 55.3%, adults = 79.2%). Rates of HBeAg among those HBsAg+ were infants = 85.1%, children = 88.1%, adolescents = 71.1%, and adults = 30.4%. The epidemiology of HBV in Vietnam resembles that of many southeast Asian nations before introduction of vaccine. Immunization of newborns will have enormous impact on HBV-related morbidity and mortality there.
机译:为了确定越南的乙型肝炎病毒(HBV)感染率,我们在清化省的两个地区调查了HBV标记。我们随机选择了536名婴儿(9岁以下或= 18个月大),228名儿童(4岁以下= 6岁),219名青少年(14岁以下= 16岁)和596名成人(25岁以下=或= 40岁)。经询问,接受调查的人中没有人接种过乙肝疫苗。在所有标本中均测量了乙型肝炎病毒表面抗原(HBsAg)和总HBV核心抗体(抗HBc),在所有HBsAg阳性的患者中均测量了HBV e抗原(HBeAg),并测量了所有HBV表面抗体(anti-HBs)其他。当前的感染率(HBsAg +)为婴儿= 12.5%,儿童= 18.4%,青少年= 20.5%,成人= 18.8%。当前或以前的感染(HBsAg +,抗-HBc +或抗-HBs +)随着年龄的增长而增加(婴儿= 19.6%,儿童= 36.4%,青少年= 55.3%,成人= 79.2%)。在这些HBsAg +中,HBeAg的发生率分别为婴儿= 85.1%,儿童= 88.1%,青少年= 71.1%,成人= 30.4%。在引入疫苗之前,越南的乙肝病毒流行病学与许多东南亚国家相似。新生儿免疫将对那里与HBV相关的发病率和死亡率产生巨大影响。

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