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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Cage trials using an endogenous meiotic drive gene in the mosquito Aedes aegypti to promote population replacement.
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Cage trials using an endogenous meiotic drive gene in the mosquito Aedes aegypti to promote population replacement.

机译：笼养试验在蚊埃及伊蚊中使用内源性减数分裂驱动基因促进种群置换。

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摘要

Control of arthropod-borne diseases based on population replacement with genetically modified non-competent vectors has been proposed as a promising alternative to conventional control strategies. Due to likely fitness costs associated with vectors manipulated to carry anti-pathogen effector genes, the effector genes will need to be coupled with a strong drive system to rapidly sweep them into natural populations. Endogenous meiotic drive systems have strong and stable population replacement potential, and have previously been reported in two mosquito species: Aedes aegypti and Culex pipiens. To investigate the influence of an endogenous meiotic drive gene on Ae. aegypti population dynamics, we established three experimental population types that were initiated with 100%, 10%, and 1% male mosquitoes carrying a strong meiotic driver (T37 strain) and 100% sensitive females (RED strain), respectively. Among the 100% and 10% populations, early generations were highly male biased, which reflected the effects of the meiotic driver, and remained more than 60% male by the F(15). A genetic marker tightly linked with the meiotic driver on chromosome 1 showed strong selection for the T37 strain-specific allele. Similar but reduced effects of the meiotic driver were also observed in the 1% populations. These results suggest that release of Ae. aegypti males carrying a strong meiotic driver into drive sensitive populations can be an effective tool for population replacement, and provide a foundation for additional studies including both experimental populations and simulations by mathematical modeling.
机译：已经提出了用基因修饰的非胜任载体替代种群来控制节肢动物传播疾病的方法，作为常规控制策略的有希望的替代方法。由于与操纵携带抗病原体效应子基因的载体相关的可能的健身成本，效应子基因将需要与强大的驱动系统耦合，以快速将其扫入自然种群。内源性减数分裂驱动系统具有强大而稳定的种群替代潜力，先前已报道过两种蚊子：埃及伊蚊和淡色库蚊。调查内源性减数分裂驱动基因对Ae的影响。在埃及种群动态中，我们建立了三种实验种群类型，分别由携带强力减数分裂驱动因子（T37株）和敏感女性（RED株）的100％，10％和1％的雄性蚊子启动。在100％和10％的人口中，早期世代的男性偏向性很高，这反映了减数分裂驱动因素的影响，而F族仍然占60％以上的男性。与1号染色体上的减数分裂驱动因子紧密相连的遗传标记显示出对T37菌株特异性等位基因的强烈选择。在1％的人群中也观察到了减数分裂驱动因子的相似但减弱的作用。这些结果表明Ae的释放。携带强力减数分裂驱动因子进入敏感种群的埃及埃及男性可以成为种群替代的有效工具，并为包括实验种群和数学建模模拟在内的其他研究奠定基础。

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