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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Transmission of hepatitis C virus between parents and children.
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Transmission of hepatitis C virus between parents and children.

机译：丙肝病毒在父母与子女之间的传播。

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摘要

Egyptian children with infected parents are at high risk of infection with hepatitis C (HCV). Analysis of data collected during surveys of rural communities show children whose parents had antibodies to HCV (anti-HCV) were at higher risk for having anti-HCV than children whose parents did not. The association was greater with mothers than fathers and when the parent had HCV RNA. For instance, 87 (14%) of 612 children had anti-HCV whose mothers had HCV RNA compared with 28 (7%) of 401 whose mothers only had anti-HCV and 79 (2.6%) of 3,086 whose mothers were seronegative. These associations persisted after controlling for age, parenteral exposures, and serologic status of the other parent. Sequencing isolates from 13 families with parent(s) and children having HCV RNA showed 10 of 18 had genetically similar viruses. These findings suggest Egyptian children are at high risk of being infected with HCV by their parents and identification of the transmission routes would allow for preventive measures.
机译：父母受感染的埃及儿童感染丙型肝炎（HCV）的风险很高。对农村社区调查收集的数据进行的分析显示，父母具有HCV抗体（抗HCV）的孩子比父母没有的孩子具有抗HCV的风险更高。母亲与父亲之间的关联比父亲与父亲之间的关联更大，而父母具有HCV RNA。例如，在612名儿童中，有87名（14％）患有抗HCV，其母亲具有HCV RNA，而在401名母亲中只有28种（占7％），其母亲只有HCV RNA，有79名（2.6％），其母亲具有血清阴性。在控制了另一位父母的年龄，肠胃外暴露和血清学状况后，这些关联仍然存在。来自父母和子女患有HCV RNA的13个家庭的测序分离株显示18个中的10个具有遗传相似的病毒。这些发现表明，埃及儿童极有可能被其父母感染HCV，识别传播途径可采取预防措施。

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