首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Simplified multi-organ dysfunction score predicts disability in African children with Plasmodium falciparum malaria.
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Simplified multi-organ dysfunction score predicts disability in African children with Plasmodium falciparum malaria.

机译:简化的多器官功能障碍评分可预测患有恶性疟原虫疟疾的非洲儿童的残疾。

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摘要

In this prospective study, we assessed the simplified multi-organ dysfunction score (sMODS) in 485 consecutive African children, hospitalized with Plasmodium falciparum malaria. Children were grouped according to their ability to walk unaided (Group 1, N = 414), sit unaided (Group 2, N = 63), or inability of both (Group 3, N = 8) before contracting malaria. The sMODS on admission to hospital was highly correlated with prolonged disease duration in Groups 1 and 2 (Spearman r = 0.79 and r = 0.78, respectively). A sMODS of > or = 16 was indicative for prolonged disease duration in Group 1 (> 48 hours of inability to walk, sensitivity of 87%, specificity of 82%) and Group 2 (> 24 hours of inability to sit, sensitivity of 100%, and specificity of 78%.). The simplified MODS is a simple and sensitive measure merit of severity of illness in children with P. falciparum malaria and allows early prognostic evaluation.
机译:在这项前瞻性研究中,我们评估了485例因恶性疟原虫疟疾住院的非洲儿童的简化多器官功能障碍评分(sMODS)。根据患疟疾前的独立行走能力(第1组,N = 414),独立行走(第2组,N = 63)或两者均无能力(第3组,N = 8)对儿童进行分组。在第1组和第2组中,入院时的sMODS与疾病持续时间高度相关(分别为Spearman r = 0.79和r = 0.78)。 sMODS大于或等于16表示第1组(> 48小时无能力行走,敏感性为87%,特异性为82%)和第2组(> 24小时无坐位,敏感性为100)的疾病持续时间延长%,特异性为78%。)。简化的MODS是恶性疟原虫疟疾患儿疾病严重程度的一种简单而敏感的衡量标准,可进行早期预后评估。

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