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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Use of area under the curve to characterize transmission potential after antimalarial treatment.
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Use of area under the curve to characterize transmission potential after antimalarial treatment.

机译：使用曲线下方的面积来表征抗疟疾治疗后的传播潜力。

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摘要

To evaluate transmission potential of Plasmodium falciparum, we use the area under the curve (AUC) of gametocyte levels after treatment as an approach to combine their duration and magnitude. Analysis of determinants of AUC was based on two main exposures: parasite clearance time (PCT) and presence of dihydrofolate reductase and dihydropteroate synthase mutations associated with sulfadoxine-pyrimethamine (SP) resistance in vitro. Exposures were determined based on the first three days after treatment with SP of 96 individuals who had malaria, cleared parasitemia by days 1-3, and were followed-up for 21 days. Using regression methods, we characterized both the heterogeneity of the presence of gametocytes (AUC > 0) and the magnitude of the AUC among those with an AUC > 0. A PCT of two or three days was associated with a substantial and highly significant odds ratio for presence of gametocytes. Among those who developed gametocytes, if their clearance time was 3 days or if they had any mutations (1 or 2) the magnitude of gametocytemia was > or = 3-fold. Methods presented are applicable to both observational studies and clinical trials assessing the effect of therapies on transmission potential.
机译：为了评估恶性疟原虫的传播潜能，我们使用处理后配子细胞水平的曲线下面积（AUC）作为组合其持续时间和强度的方法。 AUC决定因素的分析基于两个主要暴露因素：体外寄生虫清除时间（PCT）和存在二氢叶酸还原酶和二氢蝶呤合酶突变与磺胺多辛-乙胺嘧啶（SP）的耐药性相关。根据接受SP治疗后的前三天对96名患有疟疾，在1-3天后清除了寄生虫病并随访21天的个体进行暴露测定。使用回归方法，我们表征了配子细胞存在的异质性（AUC> 0）和AUC> 0的那些之间的AUC大小。两天或三天的PCT与显着且极显着的比值比相关是否存在配子体细胞。在发育配子细胞的患者中，如果清除时间为3天或有任何突变（1或2），则配子细胞减少症的幅度为>或= 3倍。提出的方法适用于观察性研究和评估疗法对传播潜能影响的临床试验。

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