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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Dhori virus (Orthomyxoviridae: Thogotovirus) infection in mice: a model of the pathogenesis of severe Orthomyxovirus infection.
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Dhori virus (Orthomyxoviridae: Thogotovirus) infection in mice: a model of the pathogenesis of severe Orthomyxovirus infection.

机译：小鼠Dhori病毒（正粘病毒科：Thogotovirus）感染：严重正粘病毒感染的发病机理模型。

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摘要

After intranasal, subcutaneous, or intraperitoneal infection with Dhori virus (DHOV), adult mice developed a fulminant and uniformly fatal illness with many of the clinical and pathologic findings seen in mice infected with H5N1 highly pathogenic avian influenza A virus. Histopathologic findings in lungs of DHOV-infected mice consisted of hemorrhage, inflammation, and thickening of the interstitium and the alveolar septa and alveolar edema. Extra-pulmonary findings included hepatocellular necrosis and steatosis, widespread severe fibrinoid necrosis in lymphoid organs, marked lymphocyte loss and karyorrhexis, and neuronal degeneration in brain. Similar systemic histopathologic findings have been reported in the few fatal human H5N1 cases examined at autopsy. Because of the relationship of DHOV to the influenza viruses, its biosafety level 2 status, and its similar pathology in mice, the DHOV-mouse model may offer a low-cost, relatively safe, and realistic animal model for studies on the pathogenesis andmanagement of H5N1 virus infection.
机译：经Dhori病毒（DHOV）鼻内，皮下或腹膜内感染后，成年小鼠出现了暴发性且均匀致命的疾病，在感染H5N1高致病性甲型禽流感病毒的小鼠中发现了许多临床和病理发现。 DHOV感染小鼠肺部的组织病理学发现包括出血，炎症，间质，肺泡间隔和肺泡水肿的增厚。肺外的发现包括肝细胞坏死和脂肪变性，淋巴器官广泛的严重的纤维蛋白样坏死，明显的淋巴细胞损失和淋巴结炎以及脑神经元变性。在尸检中检测到的几例致命的人类H5N1病例中，也报告了类似的全身组织病理学发现。由于DHOV与流感病毒的关系，其生物安全水平2的状态以及小鼠的相似病理学，DHOV小鼠模型可能为研究DHOV的发病机理和管理提供了一种低成本，相对安全和现实的动物模型。 H5N1病毒感染。

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